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与肾上腺皮质腺瘤相关的醛固酮增多症。

Aldosteronism associated with adrenal cortical adenoma.

作者信息

PRATT O B

出版信息

Calif Med. 1956 Jul;85(1):1-4.

PMID:13342995
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1532143/
Abstract

An electrolyte-regulating corticoid has been identified and given the name aldosterone. This hormone may be produced in amounts above normal in adrenal cortical tumors in hyperplastic adrenal glands and in normal appearing adrenal glands. Overproduction of aldosterone is accompanied by certain characteristic clinical manifestations which should suggest the diagnosis. The diagnosis may be supported by examinations available in most well equipped clinical laboratories. Bioassay of aldosterone in the urine and estimation of exchangeable body sodium and potassium, using radioactive salts, are necessary for confirmation of the diagnosis.Since the description of this salt-retaining hormone by Simpson and Tait and the discovery of its chemical structure by Reichstein in 1954, reports of 14 cases have been published. Surgical removal of the offending tissue gives spectacular relief from the very distressing symptoms.

摘要

一种调节电解质的皮质激素已被确认，并命名为醛固酮。这种激素在肾上腺皮质肿瘤、增生的肾上腺以及外观正常的肾上腺中，可能会高于正常量地产生。醛固酮分泌过多会伴有某些特征性临床表现，这些表现应能提示诊断。多数设备完善的临床实验室所提供的检查有助于支持这一诊断。确诊需要进行尿醛固酮生物测定以及使用放射性盐类对体内可交换钠和钾进行测定。自1954年辛普森和泰特描述了这种保盐激素并由赖希施泰因发现其化学结构以来，已发表了14例报告。手术切除病变组织能显著缓解极为痛苦的症状。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/800f/1532143/9663b4870347/califmed00259-0065-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/800f/1532143/e9c679b0a90e/califmed00259-0064-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/800f/1532143/3bbf17f55238/califmed00259-0064-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/800f/1532143/f9ccd4d22750/califmed00259-0065-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/800f/1532143/30b3596d6a2d/califmed00259-0065-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/800f/1532143/9663b4870347/califmed00259-0065-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/800f/1532143/e9c679b0a90e/califmed00259-0064-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/800f/1532143/3bbf17f55238/califmed00259-0064-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/800f/1532143/f9ccd4d22750/califmed00259-0065-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/800f/1532143/30b3596d6a2d/califmed00259-0065-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/800f/1532143/9663b4870347/califmed00259-0065-c.jpg

相似文献

1
Aldosteronism associated with adrenal cortical adenoma.与肾上腺皮质腺瘤相关的醛固酮增多症。
Calif Med. 1956 Jul;85(1):1-4.
2
Parallel biochemical and histochemical studies of an adrenocortical adenoma from a patient with primary aldosteronism.对一名原发性醛固酮增多症患者的肾上腺皮质腺瘤进行的平行生化和组织化学研究。
Acta Endocrinol (Copenh). 1961 Oct;38:207-19. doi: 10.1530/acta.0.0380207.
3
Prominent peripheral edema associated with primary aldosteronism due to an adrenocortical adenoma.由肾上腺皮质腺瘤引起的原发性醛固酮增多症相关的显著外周水肿。
J Clin Endocrinol Metab. 1960 Aug;20:1168-83. doi: 10.1210/jcem-20-8-1168.
4
Primary aldosteronism due to adrenal hyperplasia; occurrence in a boy aged 10 years.肾上腺增生所致原发性醛固酮增多症；发生于一名10岁男孩。
AMA J Dis Child. 1959 Jul;98(1):90-9. doi: 10.1001/archpedi.1959.02070020092012.
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Primary hyperaldosteronism due to left adrenal adenoma. Report of a case.左侧肾上腺腺瘤所致原发性醛固酮增多症。病例报告。
Hawaii Med J. 1962 May-Jun;21:410-2.
6
Genetics of primary hyperaldosteronism.原发性醛固酮增多症的遗传学
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7
[Hypercorticism due to adrenal adenoma with glucorticoid and androgen hypersecretion, edema and hypokalemia, severe metabolic disorders].肾上腺腺瘤伴糖皮质激素和雄激素分泌过多、水肿及低钾血症所致的皮质醇增多症，严重代谢紊乱
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[CONTRIBUTION TO DATA ON THE STRUCTURE OF ADRENAL CORTEX ADENOMA AND THE ADRENAL CORTEX IN PRIMARY ALDOSTERONISM (CONN SYNDROME)].[对原发性醛固酮增多症（康恩综合征）中肾上腺皮质腺瘤及肾上腺皮质结构数据的贡献]
Endokrinologie. 1963 Dec;45:276-95.
9
[Primary aldosteronism].[原发性醛固酮增多症]
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10
Hyperparathyroidism can be useful in the identification of primary aldosteronism due to aldosterone-producing adenoma.甲状旁腺功能亢进症有助于识别由于醛固酮腺瘤引起的原发性醛固酮增多症。
Hypertension. 2012 Aug;60(2):431-6. doi: 10.1161/HYPERTENSIONAHA.112.195891. Epub 2012 Jun 25.

引用本文的文献

1
Recent Development toward the Next Clinical Practice of Primary Aldosteronism: A Literature Review.原发性醛固酮增多症未来临床实践的最新进展：文献综述
Biomedicines. 2021 Mar 17;9(3):310. doi: 10.3390/biomedicines9030310.
2
Physiologic and surgical problems in the management of primary aldosteronism.原发性醛固酮增多症管理中的生理和外科问题
Ann Surg. 1959 Oct;150(4):653-65. doi: 10.1097/00000658-195910000-00010.

本文引用的文献

1
Secretion of a salt-retaining hormone by the mammalian adrenal cortex.哺乳动物肾上腺皮质分泌一种保盐激素。
Lancet. 1952 Aug 2;2(6727):226-8. doi: 10.1016/s0140-6736(52)91551-1.
2
Evidence for a sodium retaining factor in toxemia of pregnancy.
Proc Soc Exp Biol Med. 1951 Oct;78(1):244-6. doi: 10.3181/00379727-78-19035.
3
Isolation of crystalline aldosterone from the urine of a nephrotic patient.从一名肾病患者的尿液中分离出结晶醛固酮。
Experientia. 1954 Nov 15;10(11):456-8. doi: 10.1007/BF02170397.
4
Primary aldosteronism, a new clinical entity.原发性醛固酮增多症，一种新的临床病症。
Ann Intern Med. 1956 Jan;44(1):1-15. doi: 10.7326/0003-4819-44-1-1.
5
Isolation and identification of aldosterone from adrenal venous blood.从肾上腺静脉血中分离和鉴定醛固酮。
Proc Soc Exp Biol Med. 1954 Oct;87(1):141-3. doi: 10.3181/00379727-87-21314.
6
[Effect of electrocortin on electrolyte and water excretion in comparison with desoxycorticosterone].[与脱氧皮质酮相比，电皮质素对电解质和水排泄的影响]
Schweiz Med Wochenschr. 1953 Nov 7;83(45):1088-9.
7
Excretion of sodium-retaining substances in patients with congestive heart failure.充血性心力衰竭患者中保钠物质的排泄
Am Heart J. 1953 Jun;45(6):795-801. doi: 10.1016/0002-8703(53)90127-6.