介导兔和猪离体虹膜括约肌标本收缩的缓激肽受体亚型的不同特性。
Contrasting properties of bradykinin receptor subtypes mediating contractions of the rabbit and pig isolated iris sphincter pupillae preparation.
作者信息
Everett C M, Hall J M, Mitchell D, Morton I K
机构信息
Pharmacology Group, Biomedical Sciences Division, King's College London, UK.
出版信息
Agents Actions Suppl. 1992;38 ( Pt 2):378-81.
PMID:1334337
Abstract
Bradykinin contracts both the pig and rabbit iris sphincter preparations. In the pig, the bradykinin antagonists Lys,Lys-[Hyp3, Thi5,8,D-Phe7]-BK and D-Arg-[Hyp3,Thi5,D-Tic7,Oic8]-BK (HOE140) inhibited responses with pKB estimates of 6.0 and 8.4, respectively. These affinities are markedly lower than in the rabbit preparation, suggesting that different receptors are present in each of the two species.
摘要
缓激肽可使猪和兔的虹膜括约肌标本收缩。在猪的标本中，缓激肽拮抗剂赖氨酸、赖氨酸-[Hyp3，Thi5，8，D-Phe7]-BK和D-精氨酸-[Hyp3，Thi5，D-Tic7，Oic8]-BK（HOE140）抑制反应，其pKB估计值分别为6.0和8.4。这些亲和力明显低于兔标本中的亲和力，表明这两个物种的每一个中都存在不同的受体。
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