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大鼠十二指肠对缓激肽舒张反应的机制

Mechanism of the relaxant response of the rat duodenum to bradykinin.

作者信息

Feres T, Funari C C, Paiva A C, Paiva T B

机构信息

Department of Biophysics, Escola Paulista de Medicina, São Paulo, Brazil.

出版信息

Agents Actions Suppl. 1992;38 ( Pt 2):398-405.

PMID:1334340
Abstract

Bradykinin (BK) did not increase cyclic AMP production in cultured rat duodenum smooth muscle cells. Its relaxant effect on the tissue was inhibited by apamin and potentiated by phorbol dibutyrate (PDBU). PDBU also caused a relaxation which was inhibited by apamin. BK's relaxant effect, and its potentiation by PDBU, are due to activation of Ca(2+)-dependent K+ channels.

摘要

缓激肽（BK）不会增加培养的大鼠十二指肠平滑肌细胞中环磷酸腺苷（cAMP）的生成。其对该组织的舒张作用可被蜂毒明肽抑制，而被佛波醇二丁酸酯（PDBU）增强。PDBU也会引起一种可被蜂毒明肽抑制的舒张作用。BK的舒张作用及其被PDBU的增强作用，是由于钙依赖性钾通道的激活所致。

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