[Ca2+]i effects of bradykinin B2 receptor activation in PC12 cells.

In PC12 cells, activation of B2 receptors by bradykinin promotes an elevation of cytosolic Ca2+ by two mechanisms: IP3 mediated release of Ca2+ from intracellular stores and stimulation of multiple Ca2+ influx pathways. Since these events can have different kinetics and spatial localizations they can induce diversified effects in different cell areas.