激肽拮抗剂对清醒正常血压大鼠的局部血流动力学影响
Regional hemodynamic effects of a kinin antagonist in awake normotensive rats.
作者信息
Madeddu P, Anania V, Parpaglia P P, Demontis M P, Varoni M V, Fattaccio M C, Glorioso N
机构信息
Clinica Medica and Farmacologia, Sassari University, Italy.
出版信息
Agents Actions Suppl. 1992;38 ( Pt 3):149-55.
We evaluated the effects of the B2-receptor antagonist Ac-D-Arg[Hyp3,D-Phe7,Leu8]-bradykinin on mean blood pressure (MBP) and Doppler mesenteric blood flow (DMBF). The antagonist, at a dose able to completely block the hemodynamic effects of exogenous bradykinin, increased MBP by 3 +/- 1% and decreased DMBF by 12 +/- 3%. These responses persisted after pharmacological neuro-hormonal blockade. Our results suggest that the kallikrein-kinin system plays a role in the regulation of mesenteric blood flow in rats.
我们评估了B2受体拮抗剂Ac-D-Arg[Hyp3，D-Phe7，Leu8]-缓激肽对平均血压（MBP）和多普勒肠系膜血流量（DMBF）的影响。该拮抗剂在能够完全阻断外源性缓激肽血流动力学效应的剂量下，使MBP升高3±1%，使DMBF降低12±3%。这些反应在药理学神经激素阻断后持续存在。我们的结果表明，激肽释放酶-激肽系统在大鼠肠系膜血流调节中发挥作用。
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