激肽释放酶基因家族蛋白酶在大鼠组织中的定位

Localization of kallikrein gene family proteases in rat tissues.

作者信息

Simson J A, Chao J, Chao L

机构信息

Department Anatomy, Medical University of South Carolina, Charleston.

出版信息

Agents Actions Suppl. 1992;38 ( Pt 1):595-602. doi: 10.1007/978-3-0348-7321-5_73.

DOI:10.1007/978-3-0348-7321-5_73

PMID:1334634

Abstract

Monoclonal antibodies specific for three kallikrein gene family enzymes (tissue kallikrein, esterase A and tonin) have been used to determine the tissue and cellular distributions of these proteases as well as their association with other relevant molecules (kininogen, kallikrein-binding protein, and Na,K-ATPase alpha-subunit). Secretion of these enzymes from salivary glands was also analyzed. The results of these localization studies provide important clues to the functions of different members of this closely related family of serine proteases.

摘要

针对三种激肽释放酶基因家族酶（组织激肽释放酶、酯酶A和托宁）的单克隆抗体已被用于确定这些蛋白酶的组织和细胞分布，以及它们与其他相关分子（激肽原、激肽释放酶结合蛋白和钠钾ATP酶α亚基）的关联。还分析了这些酶从唾液腺的分泌情况。这些定位研究的结果为这个密切相关的丝氨酸蛋白酶家族不同成员的功能提供了重要线索。