Cabanes A, Arboix M, Garcia Anton J M, Reig F
Peptides Department, CID, CSIC, Barcelona, Spain.
Am J Vet Res. 1992 Nov;53(11):2090-3.
The pharmacokinetics and bioavailability of enrofloxacin were determined after IV and IM administration of 5 mg/kg of body weight to 6 healthy adult rabbits. Using nonlinear least-squares regression methods, data obtained were best described by a 2-compartment open model. After IV administration, a rapid distribution phase was followed by a slower elimination phase, with a half-life of 131.5 +/- 17.6 minutes. The mean body clearance rate was 22.8 +/- 6.8 ml/min/kg, and the mean volume of distribution was 3.4 +/- 0.9 L/kg. This large volume of distribution and the K12/K21 ratio close to 1, indicated that enrofloxacin was widely distributed in the body, but not retained in tissues. After a brief lag period (6.2 +/- 2.86 min), IM absorption was rapid (4.1 +/- 1.3 min) and almost complete. The mean extent of IM absorption was 92 +/- 11%, and maximal plasma concentration of 3.04 +/- 0.34 micrograms/ml was detected approximately 10 minutes after administration.
给6只健康成年兔静脉注射和肌肉注射5mg/kg体重的恩诺沙星后，测定了其药代动力学和生物利用度。使用非线性最小二乘回归方法，所得数据最好用二室开放模型描述。静脉注射后，快速分布相之后是较慢的消除相，半衰期为131.5±17.6分钟。平均机体清除率为22.8±6.8ml/min/kg，平均分布容积为3.4±0.9L/kg。这种较大的分布容积以及K12/K21比值接近1，表明恩诺沙星在体内广泛分布，但不潴留在组织中。经过短暂的延迟期（6.2±2.86分钟）后，肌肉注射吸收迅速（4.1±1.3分钟）且几乎完全。肌肉注射的平均吸收程度为92±11%，给药后约10分钟检测到最大血浆浓度为3.04±0.34μg/ml。
