Kudriashov B A, Pastorova V E, Liapina L A, Kondashevskaia M V
Biull Eksp Biol Med. 1992 Jul;114(8):141-3.
Complexes of low-molecular heparin with acetylsalicilic acid was formed in vitro when the weight ratio of components was 1:1, 1:5 and 5:1, respectively. All the complexes possessed fibrinolytic and anticoagulating activities. The complex possessed the highest activity when the ratio of heparin to acetylsalicilic acid was 5:1. This complex at a dose 1 mg/200 g of rat weight had the largest thrombolytic effect on the experimental fresh thrombus.
当低分子肝素与乙酰水杨酸的重量比分别为1:1、1:5和5:1时,它们在体外形成复合物。所有复合物都具有纤溶和抗凝活性。当肝素与乙酰水杨酸的比例为5:1时,复合物具有最高活性。这种复合物以1毫克/200克大鼠体重的剂量对实验性新鲜血栓具有最大的溶栓作用。