The oral toxicity of clioquinol (5-chloro-7-iodo-8-hydroxyquinoline) in beagle dogs.
作者信息
Heywood R, Chesterman H, Worden A N
出版信息
Toxicology. 1976 Jun;6(1):41-6. doi: 10.1016/0300-483x(76)90006-8.
PMID:133475
Abstract
When clioquinol was administered to Beagle dogs, disturbances in gait which were associated with abnormal reflexes and reactions, were seen in animals receiving 250 and 400 mg/kg body weight per day. Histopathological examination of the central nervous system (CNS) showed pathological change in the posterior columns of the spinal cord.
摘要
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