Albin R L, Gilman S
Department of Neurology, University of Michigan, Ann Arbor 48109.
Brain Res. 1992 Nov 6;595(1):164-6. doi: 10.1016/0006-8993(92)91469-u.
We used receptor autoradiography to ascertain the distribution of GABAA and GABAB binding sites in the cerebellar cortex of the red-eared turtle (Pseudemys scripta). GABAA binding sites were found in both molecular and granule cell layers with highest levels in the granule cell layer. GABAB binding sites were found at highest level in the molecular layer. Benzodiazepine binding sites were found in approximately equal abundance in both layers. Little binding of any ligand was seen in the Purkinje cell layer. Our results are similar to those found in mammals and other non-mammalian vertebrates and indicate that the organization of inhibitory pathways of the cerebellar cortex has been conserved in the course of vertebrate evolution.
我们使用受体放射自显影技术来确定红耳龟（滑龟）小脑皮质中GABAA和GABAB结合位点的分布。在分子层和颗粒细胞层均发现了GABAA结合位点，其中颗粒细胞层中的水平最高。GABAB结合位点在分子层中的水平最高。苯二氮䓬结合位点在两层中的丰度大致相等。在浦肯野细胞层中几乎未观察到任何配体的结合。我们的结果与在哺乳动物和其他非哺乳动物脊椎动物中发现的结果相似，表明小脑皮质抑制性通路的组织在脊椎动物进化过程中得以保留。
