慢性低氧血症绵羊胎儿对促肾上腺皮质激素释放因子的促肾上腺皮质激素和皮质醇反应

Corticotropin and cortisol responses to corticotropin-releasing factor in the chronically hypoxemic ovine fetus.

作者信息

Kerr D R, Castro M I, Valego N K, Rawashdeh N M, Rose J C

机构信息

Department of Physiology/Pharmacology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27157-1083.

出版信息

Am J Obstet Gynecol. 1992 Dec;167(6):1686-90. doi: 10.1016/0002-9378(92)91762-y.

DOI:10.1016/0002-9378(92)91762-y

PMID:1335209

Abstract

OBJECTIVE

The purpose of this study was to determine if mild hypoxemia (approximately 25% below normal) of at least 5 days' duration alters corticotropin and cortisol responses to corticotropin-releasing factor.

STUDY DESIGN

We studied 14 (hypoxemic, n = 5; normoxemic, n = 9) fetuses of 135 +/- 1 (mean +/- SEM) days' gestational age. Fetuses were placed in the experimental group if arterial PO2 was < or = 16 mm Hg for 5 days. In normoxemic animals arterial PO2 was > or = 17 mm Hg. Plasma hormone responses were compared by analysis of variance.

RESULTS

Resting corticotropin levels were not different (hypoxemic 26 +/- 5 pg/ml, normoxemic 29 +/- 12 pg/ml), and corticotropin-releasing factor (530 +/- 30 ng/kg) increased (p = 0.01) corticotropin levels similarly in both groups. Basal plasma cortisol levels (hypoxemic 20 +/- 10 ng/ml, normoxemic, 30 +/- 7 ng/ml) were not significantly different. Both groups had similarly increased (p < 0.01) plasma cortisol levels after corticotropin-releasing factor administration.

CONCLUSION

Mild hypoxemia lasting 5 days does not significantly alter corticotropin and cortisol responses to corticotropin-releasing factor in the late-gestation ovine fetus.

摘要

目的

本研究旨在确定持续至少5天的轻度低氧血症（比正常水平低约25%）是否会改变促肾上腺皮质激素以及皮质醇对促肾上腺皮质激素释放因子的反应。

研究设计

我们研究了135±1（均值±标准误）日龄的14例胎儿（低氧血症组，n = 5；正常氧血症组，n = 9）。如果动脉血氧分压≤16 mmHg持续5天，则将胎儿纳入实验组。正常氧血症动物的动脉血氧分压≥17 mmHg。通过方差分析比较血浆激素反应。

结果

静息促肾上腺皮质激素水平无差异（低氧血症组26±5 pg/ml，正常氧血症组29±12 pg/ml），促肾上腺皮质激素释放因子（530±30 ng/kg）使两组促肾上腺皮质激素水平均升高（p = 0.01），且升高程度相似。基础血浆皮质醇水平（低氧血症组20±10 ng/ml，正常氧血症组30±7 ng/ml）无显著差异。给予促肾上腺皮质激素释放因子后，两组血浆皮质醇水平均有相似程度的升高（p < 0.01）。