家兔离体中耳动脉在体内慢性电刺激后嘌呤能反应的变化。
Changes in purinergic responses of the rabbit isolated central ear artery after chronic electrical stimulation in vivo.
作者信息
Maynard K I, Loesch A, Burnstock G
机构信息
Department of Anatomy and Developmental Biology, University College London.
出版信息
Br J Pharmacol. 1992 Nov;107(3):833-6. doi: 10.1111/j.1476-5381.1992.tb14532.x.
Abstract
- The effect of chronic (4-16 days) electrical stimulation (5 Hz, 0.3 ms, 4-10 V) of the great auricular nerve in vivo on sympathetic cotransmission in the rabbit isolated central ear artery was examined. 2. Chronic stimulation had no significant effect on frequency-dependent (4-60 Hz) neurogenic contractions or contractile responses induced by exogenous noradrenaline (0.1-300 microM). 3. In contrast, contractions induced by exogenous alpha, beta-methylene ATP (10.0 microM) were significantly decreased in preparations from 16-day stimulated animals in comparison with sham-operated, 4-day and 8-day chronically stimulated animal groups. 4. It is concluded that chronic electrical stimulation of nerves supplying the ear artery may lead to the selective alteration of postjunctional P2x-purinoceptor mechanisms, while the effects mediated by post-junctional alpha 1-adrenoceptors remain unchanged.
摘要
- 研究了体内慢性（4 - 16天）电刺激（5Hz，0.3ms，4 - 10V）耳大神经对兔离体中耳动脉交感神经共同传递的影响。2. 慢性刺激对外源性去甲肾上腺素（0.1 - 300μM）诱导的频率依赖性（4 - 60Hz）神经源性收缩或收缩反应无显著影响。3. 相比之下，与假手术、4天和8天慢性刺激动物组相比，16天刺激动物的制剂中，外源性α，β - 亚甲基ATP（10.0μM）诱导的收缩明显降低。4. 得出结论，慢性电刺激供应耳动脉的神经可能导致节后P2x嘌呤受体机制的选择性改变，而节后α1 - 肾上腺素受体介导的效应保持不变。
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