甲状腺素治疗对猫慢收缩和快收缩骨骼肌收缩及其环磷酸腺苷水平的影响。
The effects of thyroxine treatment on slow- and fast-contracting skeletal muscle contractions of the cat and their cyclic AMP level.
作者信息
Merican Z, Sukumaran S, Raji V L, Rajikin M H, Khalid B A
机构信息
Department of Pharmacology, Universiti Kebangsaan Malaysia, Kuala Lumpur.
出版信息
Clin Exp Pharmacol Physiol. 1992 Dec;19(12):843-6. doi: 10.1111/j.1440-1681.1992.tb00424.x.
Abstract
- The effects of thyroxine treatment on soleus and extensor digitorum longus (EDL) muscle contractions and their cyclic adenosine 3',5'-monophosphate (cyclic AMP) levels were examined in anaesthetized cats. 2. Thyroxine treatment decreased the tension of incomplete tetanic contractions of the soleus as well as the EDL muscles. The effect on tension of these muscles was not associated with an increase in the cyclic AMP level of the muscle as is the case with a beta 2-adrenoceptor agonist effect. 3. The results do not support the involvement of cyclic AMP in the tension depressant effect of thyroxine on contractions of skeletal muscle. 4. It is suggested that the muscle weakness and tremor observed in thyrotoxicosis and during administration of beta 2-adrenoceptor agonists are mediated by different mechanisms.
摘要
- 在麻醉猫身上研究了甲状腺素治疗对比目鱼肌和趾长伸肌（EDL）收缩及其环磷酸腺苷（cAMP）水平的影响。2. 甲状腺素治疗降低了比目鱼肌以及EDL肌肉不完全强直收缩的张力。对这些肌肉张力的影响与β2 -肾上腺素能受体激动剂作用不同，其并不伴随着肌肉cAMP水平的升高。3. 结果不支持cAMP参与甲状腺素对骨骼肌收缩的张力抑制作用。4. 提示甲状腺毒症和β2 -肾上腺素能受体激动剂给药期间观察到的肌肉无力和震颤是由不同机制介导的。
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