Junien J L, Wettstein J G
Institut de Recherche Jouveinal, Fresnes, France.
Life Sci. 1992;51(26):2009-18. doi: 10.1016/0024-3205(92)90150-n.
Several pharmacological, neurophysiological and immunohistological studies indicate that exogenous or endogenous opioids can have antinociceptive effects by acting at peripheral sites. Although modulation of mu, delta and kappa receptors can mediate these effects, the nature of the noxious stimulus and the underlying pathological condition may affect the types of opioid receptors involved. Thus, it would be appropriate to develop peripherally-acting opioid analgesics that do not have the untoward central side effects often associated with conventional analgesic drugs. This paper reviews the evidence supportive of a peripheral mechanism of action for opioids.
多项药理学、神经生理学和免疫组织学研究表明，外源性或内源性阿片类药物可通过作用于外周部位产生抗伤害感受作用。尽管μ、δ和κ受体的调节可介导这些效应，但有害刺激的性质和潜在病理状况可能会影响所涉及的阿片类受体类型。因此，开发不具有传统镇痛药常见不良中枢副作用的外周作用阿片类镇痛药是合适的。本文综述了支持阿片类药物外周作用机制的证据。
