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1
Management of nephrosis; the use of long continued hormone therapy.肾病的治疗；长期持续激素疗法的应用。
Calif Med. 1956 Sep;85(3):152-6.
2
Nephrosis of childhood: statistical evaluation of the effect of adrenocortical-active therapy.儿童肾病：肾上腺皮质活性疗法效果的统计学评估
J Chronic Dis. 1956 Jun;3(6):640-50. doi: 10.1016/0021-9681(56)90160-6.
3
[ACTH therapy of nephrosis in children].[儿童肾病的促肾上腺皮质激素治疗]
Med Klin. 1956 Jun 15;51(24):1024-31.
4
[Hormone therapy in lipoidic nephrosis].[脂质性肾病中的激素治疗]
Bull Mem Soc Med Hop Paris. 1954;55(3):238-51.
5
[ACTH therapy in nephrosis].[促肾上腺皮质激素疗法治疗肾病]
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6
Adrenocorticotrophic hormone (ACTH) therapy of the nephrotic syndrome in children.儿童肾病综合征的促肾上腺皮质激素（ACTH）治疗
Pediatrics. 1952 Nov;10(5):543-66.
7
[Favorable development of a lipoid nephrosis treated with ACTH and cortancyl, with return of the blood protein and lipid rate to normal].
Maroc Med. 1956 May;35(372):511-2.
8
Lipoid nephrosis in children; physiopathological study and therapeutic indications.儿童脂性肾病；生理病理学研究与治疗指征
Arch Fr Pediatr. 1954;11(8):843-67.
9
Nephrosis in children, a case report.儿童肾病，病例报告。
J Maine Med Assoc. 1955 Jan;46(1):6-7.
10
[Use of ACTH at the onset of lipoid nephrosis].[在脂性肾病发病时使用促肾上腺皮质激素]
Ann Paediatr. 1956 Jan;186(1):19-35.

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Hematopoietic-specific melanocortin 1 receptor signaling protects against nephrotoxic serum nephritis and mediates the beneficial effect of melanocortin therapy.造血细胞特异性黑色素皮质素 1 受体信号转导可预防抗血清性肾炎，并介导黑色素皮质素治疗的有益作用。
Kidney Int. 2023 Feb;103(2):331-342. doi: 10.1016/j.kint.2022.09.025. Epub 2022 Oct 28.
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Melanocortin therapy ameliorates podocytopathy and proteinuria in experimental focal segmental glomerulosclerosis involving a podocyte specific non-MC1R-mediated melanocortinergic signaling.黑素皮质素疗法改善实验性局灶节段性肾小球硬化症的足细胞病变和蛋白尿，涉及足细胞特异性非 MC1R 介导的黑素皮质素能信号传导。
Clin Sci (Lond). 2020 Apr 17;134(7):695-710. doi: 10.1042/CS20200016.
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MC1R is dispensable for the proteinuria reducing and glomerular protective effect of melanocortin therapy.黑素皮质素疗法降低蛋白尿和保护肾小球的作用并不依赖于MC1R。
Sci Rep. 2016 Jun 8;6:27589. doi: 10.1038/srep27589.
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Leveraging melanocortin pathways to treat glomerular diseases.利用黑皮质素途径治疗肾小球疾病。
Adv Chronic Kidney Dis. 2014 Mar;21(2):134-51. doi: 10.1053/j.ackd.2013.09.004.
6
The renaissance of corticotropin therapy in proteinuric nephropathies.促肾上腺皮质激素治疗蛋白尿性肾病的复兴。
Nat Rev Nephrol. 2011 Dec 6;8(2):122-8. doi: 10.1038/nrneph.2011.190.

本文引用的文献

1
TREATMENT OF NEPHROSIS WITH CONCENTRATED HUMAN SERUM ALBUMIN. I. EFFECTS ON THE PROTEINS OF BODY FLUIDS.用人浓缩血清白蛋白治疗肾病。I. 对体液蛋白质的影响
J Clin Invest. 1949 Jul;28(4):700-12. doi: 10.1172/JCI102121.
2
Effect of corticotropin (ACTH) on glomerular permeability to albumin and on blood antidiuretic hormone concentration in children with the nephrotic syndrome.促肾上腺皮质激素（ACTH）对肾病综合征患儿肾小球白蛋白通透性及血抗利尿激素浓度的影响。
AMA Am J Dis Child. 1952 Jan;83(1):87-91.
3
Effect of corticotropin (ACTH) on children with the nephrotic syndrome.促肾上腺皮质激素（ACTH）对肾病综合征患儿的影响。
J Am Med Assoc. 1951 Nov 17;147(12):1101-6. doi: 10.1001/jama.1951.03670290009004.
4
Nephrotic syndrome in rats.大鼠肾病综合征
Pediatrics. 1951 May;7(5):691-706.
5
The effect of adrenocorticotrophic hormone on children with the nephrotic syndrome. II. Physiologic observations on discrete kidney functions and plasma volume.促肾上腺皮质激素对肾病综合征患儿的影响。II. 对离散肾功能和血浆容量的生理学观察。
J Clin Invest. 1951 Feb;30(2):227-35. doi: 10.1172/JCI102437.
6
Treatment of nephrosis with cortisone.用可的松治疗肾病。
J Clin Invest. 1950 Dec;29(12):1576-87. doi: 10.1172/JCI102399.
7
Treatment of the nephrotic syndrome with corticotropin (ACTH) and cortisone; a four-and-one-half-year survey of results with short-term courses.用促肾上腺皮质激素（ACTH）和可的松治疗肾病综合征；对短期疗程结果的四年半调查
AMA Am J Dis Child. 1955 Jul;90(1):22-7. doi: 10.1001/archpedi.1955.04030010024004.
8
Problems of electrolyte and water balance in nephrotic syndrome.肾病综合征中的电解质和水平衡问题。
AMA Arch Intern Med. 1955 Mar;95(3):380-4. doi: 10.1001/archinte.1955.00250090018004.
9
Treatment of the nephrotic syndrome in children.儿童肾病综合征的治疗
Can Med Assoc J. 1955 Dec 15;73(12):959-64.
10
Use of malaria therapy in the nephrotic syndrome.疟疾疗法在肾病综合征中的应用。
J Am Med Assoc. 1956 Jan 7;160(1):25-30. doi: 10.1001/jama.1956.02960360027006.

肾病的治疗；长期持续激素疗法的应用。

Management of nephrosis; the use of long continued hormone therapy.

作者信息

PIEL C F

出版信息

Calif Med. 1956 Sep;85(3):152-6.

PMID:13356174
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1531946/
Abstract

The course of nephrosis in 36 children was evaluated. Twelve of 24 who received no treatment or short-term courses of steroids died. Eleven of the 24 had been well for six months to five years at the time of this report. Twelve patients received steroids by schedule over extended periods. One died and eleven had been free of signs and symptoms of nephrosis for four to eighteen months at the time of report. In only two cases was therapy discontinued. It seems evident that these patients are experiencing a better state of well-being. Whether or not the prognosis is being altered for any single patient cannot be determined.

摘要

对36名儿童的肾病病程进行了评估。24名未接受治疗或接受短期类固醇治疗的儿童中有12名死亡。在撰写本报告时，24名儿童中有11名已经病情稳定6个月至5年。12名患者长期按计划接受类固醇治疗。1名患者死亡，11名患者在报告时已无肾病体征和症状4至18个月。仅2例停止了治疗。显然，这些患者的健康状况较好。但无法确定任何一名患者的预后是否正在改变。