Hauser H, Beham A, Steindorfer P, Smola M G, Fruhwirth H, Klimpfinger M
Universitätsklinik für Chirurgie, Graz.
Wien Klin Wochenschr. 1992;104(23):717-20.
The patient's age, tumour size, histological type and degree of differentiation as well as involvement of axillary lymph nodes are decisive for prognosis and therapy of breast cancer. Moreover these parameters reflect the achievement of early diagnosis and the surgical standard of treatment of breast carcinomas. Therefore we retrospectively reviewed 1510 cases diagnosed from 1984-1987. Non-invasive carcinomas were diagnosed in 4%. 75% of them were classified as intraductal carcinoma and 25% as lobular carcinoma in situ. 96% of the tumours were invasive at time of diagnosis. Invasive ductal carcinoma (NOS-type) was found in 70.2%, invasive lobular carcinoma in 12.3%. 3.2% of the tumours showed both ductal and lobular differentiation and 2.3% corresponded to invasive ductal carcinoma with a predominantly intraductal component. Medullary and mucinous carcinomas were detected in 2.1% and 2% of cases, respectively. Papillary carcinomas were observed in 0.9%, the frequency of other histological types was less than 1%. 44% of the tumours corresponded to UICC-category pT1, 38% to pT2, 6% to pT3 and 8% to pT4. A meaningful correlation of tumour size and axillary lymph node involvement was possible in only 906 cases, in which 10 or more lymph nodes were verified histologically. Lymph node metastases were detected in 23% of tumour category pT1 and in 47% of category pT2. PT3- and pT4-tumours metastasized to axillary lymph nodes in 77 and 86% of cases, respectively.
患者的年龄、肿瘤大小、组织学类型、分化程度以及腋窝淋巴结受累情况对于乳腺癌的预后和治疗具有决定性意义。此外，这些参数反映了早期诊断的成果以及乳腺癌的外科治疗标准。因此，我们回顾性分析了1984年至1987年确诊的1510例病例。4%为非浸润性癌。其中75%为导管内癌，25%为小叶原位癌。96%的肿瘤在诊断时为浸润性。浸润性导管癌（NOS型）占70.2%，浸润性小叶癌占12.3%。3.2%的肿瘤同时具有导管和小叶分化，2.3%符合以导管内成分为主的浸润性导管癌。髓样癌和黏液癌分别在2.1%和2%的病例中被检测到。乳头状癌占0.9%，其他组织学类型的频率低于1%。44%的肿瘤符合UICC分类pT1，38%为pT2，6%为pT3，8%为pT4。仅在906例病例中能够建立肿瘤大小与腋窝淋巴结受累之间有意义的相关性，其中10个或更多淋巴结经组织学证实。pT1肿瘤类别中有23%检测到淋巴结转移，pT2类别中为47%。pT3和pT4肿瘤分别在77%和86%的病例中转移至腋窝淋巴结。
