抑制过程中心肌膜特性的变化。
Changes in membrane characteristics of heart muscle during inhibition.
作者信息
EDWARDS C, KUFFLER S W, TRAUTWEIN W
出版信息
J Gen Physiol. 1956 Sep 20;40(1):135-45. doi: 10.1085/jgp.40.1.135.
Abstract
Membrane characteristics were studied in isolated muscle strands from auricles of frogs using the "square pulse" technique. Changes in the time course and spatial spread of subthreshold electrotonic potentials were measured. If acetylcholine is applied in concentrations which cause slowing or stoppage of the heart beat, the following changes are produced: (a) the length constant (lambda) of the membrane is reduced, (b) the time constant is shortened. The effects are reversible and increase with acetylcholine concentration. The membrane changes caused by acetylcholine dimmish with time. It is concluded that during acetylcholine inhibition, as well as during vagal inhibition, the conductance of the muscle membrane is increased. Appreciable changes in the resting membrane potential need not accompany inhibition.
摘要
使用“方波脉冲”技术，对从青蛙心耳分离出的肌肉束的膜特性进行了研究。测量了阈下电紧张电位的时间进程和空间传播的变化。如果以导致心跳减慢或停止的浓度应用乙酰胆碱，会产生以下变化：(a) 膜的长度常数（λ）减小，(b) 时间常数缩短。这些效应是可逆的，并且随着乙酰胆碱浓度的增加而增强。由乙酰胆碱引起的膜变化会随时间减弱。得出的结论是，在乙酰胆碱抑制期间以及迷走神经抑制期间，肌肉膜的电导增加。抑制过程中静息膜电位不一定会有明显变化。
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