乙酰胆碱对蛙心耳小梁背景电导的作用。
The action of acetylcholine on background conductance in frog atrial trabeculae.
作者信息
Garnier D, Nargeot J, Ojeda C, Rougier O
出版信息
J Physiol. 1978 Jan;274:381-96. doi: 10.1113/jphysiol.1978.sp012154.
Abstract
The action of acetylcholine (ACh) on membrane potential and currents in frog atrial muscle has been studied with a double sucrose gap technique. The results show the following. 1. ACh induces the development of an extra current, outward at the resting potential, which is dependent on the ACh concentration. 2. The preparation does not show any sign of desensitization. 3. The reversal potential of the current induced by ACh is between 0 and 20 mV more negative than the resting potential and behaves as a K electrode. 4. The mechanism of ACh-induced K conductance presents inward going rectification properties. 5. The delayed outward current is not affected by ACh. However the evolution of its tail current seems to indicate a process of K accumulation related to the ACh-induced current.
摘要
采用双蔗糖间隙技术研究了乙酰胆碱（ACh）对蛙心房肌膜电位和电流的作用。结果如下：1. ACh诱导产生一种额外电流，在静息电位时为外向电流，其大小取决于ACh浓度。2. 标本未表现出任何脱敏迹象。3. ACh诱导的电流反转电位比静息电位负0至20mV，表现为钾电极特性。4. ACh诱导的钾电导机制具有内向整流特性。5. 延迟外向电流不受ACh影响。然而，其尾电流的变化似乎表明存在一个与ACh诱导电流相关的钾积累过程。
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本文引用的文献
1
Generation and conduction of impulses in the heart as affected by drugs.
Pharmacol Rev. 1963 Jun;15:277-332.
2
[Mechanism of membrane effect of acetylcholine on myocardial fibers].
Pflugers Arch Gesamte Physiol Menschen Tiere. 1958;266(3):324-34. doi: 10.1007/BF00416781.
3
Vagal and sympathetic effects on the pacemaker fibers in the sinus venosus of the heart.
J Gen Physiol. 1956 May 20;39(5):715-33. doi: 10.1085/jgp.39.5.715.
4
On the negative inotropic effect in the cat's auricle.
J Physiol. 1953 Jun 29;120(4):449-64. doi: 10.1113/jphysiol.1953.sp004910.
5
Cardiac cellular potentials; effect of vagal stimulation and acetylcholine.
Am J Physiol. 1953 May;173(2):312-20. doi: 10.1152/ajplegacy.1953.173.2.312.
6
Effects of acetylcholine on transmembrane potentials in frog ventricle.
Am J Physiol. 1967 Feb;212(2):451-5. doi: 10.1152/ajplegacy.1967.212.2.451.
7
Membrane currents underlying delayed rectification and pace-maker activity in frog atrial muscle.
J Physiol. 1969 Oct;204(3):717-36. doi: 10.1113/jphysiol.1969.sp008940.
8
Outward membrane currents activated in the plateau range of potentials in cardiac Purkinje fibres.
J Physiol. 1969 Jan;200(1):205-31. doi: 10.1113/jphysiol.1969.sp008689.
9
The kinetics and rectifier properties of the slow potassium current in cardiac Purkinje fibres.
J Physiol. 1968 Mar;195(1):185-214. doi: 10.1113/jphysiol.1968.sp008454.
10
Voltage clamp experiments on frog atrial heart muscle fibres with the sucrose gap technique.
Pflugers Arch Gesamte Physiol Menschen Tiere. 1968;301(2):91-108. doi: 10.1007/BF00362729.
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