乙酰胆碱对蛙心耳小梁背景电导的作用。
The action of acetylcholine on background conductance in frog atrial trabeculae.
作者信息
Garnier D, Nargeot J, Ojeda C, Rougier O
出版信息
J Physiol. 1978 Jan;274:381-96. doi: 10.1113/jphysiol.1978.sp012154.
Abstract
The action of acetylcholine (ACh) on membrane potential and currents in frog atrial muscle has been studied with a double sucrose gap technique. The results show the following. 1. ACh induces the development of an extra current, outward at the resting potential, which is dependent on the ACh concentration. 2. The preparation does not show any sign of desensitization. 3. The reversal potential of the current induced by ACh is between 0 and 20 mV more negative than the resting potential and behaves as a K electrode. 4. The mechanism of ACh-induced K conductance presents inward going rectification properties. 5. The delayed outward current is not affected by ACh. However the evolution of its tail current seems to indicate a process of K accumulation related to the ACh-induced current.
摘要
采用双蔗糖间隙技术研究了乙酰胆碱（ACh）对蛙心房肌膜电位和电流的作用。结果如下：1. ACh诱导产生一种额外电流，在静息电位时为外向电流，其大小取决于ACh浓度。2. 标本未表现出任何脱敏迹象。3. ACh诱导的电流反转电位比静息电位负0至20mV，表现为钾电极特性。4. ACh诱导的钾电导机制具有内向整流特性。5. 延迟外向电流不受ACh影响。然而，其尾电流的变化似乎表明存在一个与ACh诱导电流相关的钾积累过程。
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