Weiss R A
Laboratoire de Rétrovirologie Moléculaire, Institut Pasteur, Paris, France.
Semin Cancer Biol. 1992 Oct;3(5):321-8.
Retroviruses have long been associated with cancer in many species. Human T cell leukaemia virus type I causes adult T cell leukaemia. Human immunodeficiency virus infection is associated with lymphoma and Kaposi sarcoma, but oncogenesis is largely secondary to its effect on the immune system. The incidence of Kaposi sarcoma varies greatly in different social groups with AIDS, being most frequent among male homosexuals; an unknown, sexually transmissible agent may be responsible. Human endogenous retroviral genomes are linked with myeloproliferative disease. Finally, the risk is discussed that cancer could be a side-effect of the use of retroviral vectors in human gene therapy.
逆转录病毒长期以来一直与许多物种的癌症有关。I型人类T细胞白血病病毒可引发成人T细胞白血病。人类免疫缺陷病毒感染与淋巴瘤和卡波西肉瘤有关，但肿瘤发生在很大程度上是其对免疫系统影响的继发性结果。卡波西肉瘤的发病率在不同的艾滋病社会群体中差异很大，在男性同性恋者中最为常见；一种未知的性传播媒介可能是病因。人类内源性逆转录病毒基因组与骨髓增殖性疾病有关。最后，讨论了癌症可能是人类基因治疗中使用逆转录病毒载体的副作用这一风险。
