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Carbonic anhydrase inhibition. V. N5-substituted 2-acetylamino-1,3,4-thiadiazole-5-sulfonamides: metabolic conversion and use as control substances.

作者信息

MAREN T H

出版信息

J Pharmacol Exp Ther. 1956 Aug;117(4):385-401.

PMID:13358050
Abstract
摘要

相似文献

1
Carbonic anhydrase inhibition. V. N5-substituted 2-acetylamino-1,3,4-thiadiazole-5-sulfonamides: metabolic conversion and use as control substances.碳酸酐酶抑制作用。V. N5-取代的2-乙酰氨基-1,3,4-噻二唑-5-磺酰胺：代谢转化及作为对照物质的用途。
J Pharmacol Exp Ther. 1956 Aug;117(4):385-401.
2
[Effect of the carbonic anhydrase inhibitor 2-acetylamino-1,3,4-thiadiazole-5-sulfonamide (acetazolamide) on citric acid excretion in the urine].[碳酸酐酶抑制剂2-乙酰氨基-1,3,4-噻二唑-5-磺酰胺（乙酰唑胺）对尿液中柠檬酸排泄的影响]
Klin Wochenschr. 1958 Jul 1;36(13):633-6. doi: 10.1007/BF01480781.
3
Inhibition of bovine carbonic anhydrase by new sulfonamide compounds.新型磺胺类化合物对牛碳酸酐酶的抑制作用。
Biochemistry (Mosc). 2001 Sep;66(9):982-3. doi: 10.1023/a:1012365424900.
4
[Specific inhibition of kidney carbonic anhydrase in a histological section by means of 2-acetylamino-1, 3, 4-thiadiazole-5-sulfonamide; simultaneous contribution to the histopography of carbonic anhydrase in kidney tissue].[通过2-乙酰氨基-1,3,4-噻二唑-5-磺酰胺对组织学切片中肾脏碳酸酐酶的特异性抑制；对肾脏组织中碳酸酐酶组织定位的同步贡献]
Acta Histochem. 1955 Sep 26;2(1-2):39-46.
5
Inhibition of gastric secretion of acid in dogs by carbonic anhydrase inhibitor, 2-acetylamino-1, 3, 4-thiadiazole-5-sulfonamide.碳酸酐酶抑制剂2-乙酰氨基-1,3,4-噻二唑-5-磺酰胺对犬胃酸分泌的抑制作用
Am J Physiol. 1952 Nov;171(2):325-30. doi: 10.1152/ajplegacy.1952.171.2.325.
6
2-Substituted 1, 3, 4-thiadiazole-5-sulfonamides as carbonic anhydrase inhibitors: their effects on the transepithelial potential difference of the isolated rabbit ciliary body and on the intraocular pressure of the living rabbit eye.2-取代的1,3,4-噻二唑-5-磺酰胺类作为碳酸酐酶抑制剂：它们对离体兔睫状体跨上皮电位差及对活体兔眼眼压的影响。
Exp Eye Res. 1986 Dec;43(6):981-95. doi: 10.1016/0014-4835(86)90076-x.
7
Inhibition of pancreatic secretion by the carbonic anhydrase inhibitor 2-acetylamino-1,3,4-thiadiazole-5-sulfonamide, diamox (#6063).碳酸酐酶抑制剂2-乙酰氨基-1,3,4-噻二唑-5-磺酰胺（醋氮酰胺，#6063）对胰腺分泌的抑制作用
Am J Physiol. 1953 Aug;174(2):191-5. doi: 10.1152/ajplegacy.1953.174.2.191.
8
Inhibition of cerebrospinal fluid formation by a carbonic anhydrase inhibitor, 2-acetylamino-1,3,4-thiadiazole-5-sulfonamide (diamox).碳酸酐酶抑制剂2-乙酰氨基-1,3,4-噻二唑-5-磺酰胺（醋氮酰胺）对脑脊液生成的抑制作用
Proc Soc Exp Biol Med. 1954 Nov;87(2):373-6. doi: 10.3181/00379727-87-21386.
9
Inhibition of pancreatic secretion by the carbonic anhydrase inhibitor, 2-acetylamino-1,3,4, thiadiazole-5-sulfonamide (compound No. 6063).
Proc Soc Exp Biol Med. 1952 Oct;81(1):23-4. doi: 10.3181/00379727-81-19767.
10
[PROGRESS OF CARBONIC ANHYDRASE INHIBITORS].[碳酸酐酶抑制剂的研究进展]
Sogo Rinsho. 1964 May;13:847-57.

引用本文的文献

1
Is N-methylacetazolamide a possible new therapy against ischemia-reperfusion injury?N-甲基乙酰唑胺能否成为治疗缺血再灌注损伤的一种新疗法？
Front Pharmacol. 2023 Aug 10;14:1223132. doi: 10.3389/fphar.2023.1223132. eCollection 2023.
2
Acetazolamide prevents hypoxia-induced reactive oxygen species generation and calcium release in pulmonary arterial smooth muscle.乙酰唑胺可防止低氧诱导的肺动脉平滑肌中活性氧的产生和钙释放。
Pulm Circ. 2021 Oct 5;11(4):20458940211049948. doi: 10.1177/20458940211049948. eCollection 2021 Oct-Dec.
3
Structure and mechanism of secondary sulfonamide binding to carbonic anhydrases.
磺胺类药物与碳酸酐酶结合的结构与机制。
Eur Biophys J. 2021 Oct;50(7):993-1011. doi: 10.1007/s00249-021-01561-1. Epub 2021 Jul 30.
4
The noncarbonic anhydrase inhibiting acetazolamide analog N-methylacetazolamide reduces the hypercapnic, but not hypoxic, ventilatory response.非碳酸酐酶抑制性乙酰唑胺类似物N-甲基乙酰唑胺可降低高碳酸血症引起的通气反应，但对低氧血症引起的通气反应无影响。
Physiol Rep. 2015 Aug;3(8). doi: 10.14814/phy2.12484.
5
Pulmonary vasodilation by acetazolamide during hypoxia: impact of methyl-group substitutions and administration route in conscious, spontaneously breathing dogs.乙酰唑胺在低氧状态下对肺血管的舒张作用：甲基取代和给药途径对清醒、自主呼吸犬的影响
J Appl Physiol (1985). 2014 Apr 1;116(7):715-23. doi: 10.1152/japplphysiol.01235.2013. Epub 2014 Jan 30.
6
On the metabolism of methylated disulphonamides with a diuretic action. A contribution to the mechanism of action of chlorothiazide and similar compounds.关于具有利尿作用的甲基化二磺酰胺的代谢。对氯噻嗪及类似化合物作用机制的一项贡献。
Br J Pharmacol Chemother. 1962 Feb;18(1):61-4. doi: 10.1111/j.1476-5381.1962.tb01150.x.
7
Effect of neptazane on intra-ocular pressure in relation to its systemic action and its clinical application.醋甲唑胺对眼压的影响及其全身作用和临床应用
Br J Ophthalmol. 1960 Jul;44(7):415-29. doi: 10.1136/bjo.44.7.415.
8
The diuretic effects of large doses of acetazolamide and an analog lacking carbonic anhydrase inhibiting activity.大剂量乙酰唑胺及一种缺乏碳酸酐酶抑制活性的类似物的利尿作用。
J Clin Invest. 1960 Oct;39(10):1551-9. doi: 10.1172/JCI104176.
9
The role of carbonic anhydrase in renal reabsorption of bicarbonate.碳酸酐酶在肾脏重吸收碳酸氢根中的作用。
J Physiol. 1959 Mar 3;145(2):277-88. doi: 10.1113/jphysiol.1959.sp006142.
10
Specificity and comparative activity of the carbonic anhydrase inhibitors neptazane and diamox on animal and human eyes.碳酸酐酶抑制剂奈哌齐特和醋甲唑胺对动物和人眼的特异性及比较活性。
Br J Ophthalmol. 1958 Oct;42(10):577-88. doi: 10.1136/bjo.42.10.577.