大鼠胃动力的中枢去甲肾上腺素能抑制作用。

Central noradrenergic inhibition of gastric motility in rats.

作者信息

Nagata M, Osumi Y

机构信息

Department of Pharmacology, Kochi Medical School, Japan.

出版信息

Eur J Pharmacol. 1992 Nov 17;223(2-3):153-6. doi: 10.1016/0014-2999(92)94833-h.

DOI:10.1016/0014-2999(92)94833-h

PMID:1335879

Abstract

The roles of central noradrenergic mechanisms in the regulation of gastric motility were investigated in urethane-anesthetized rats in whom an intragastric balloon had been placed. Noradrenaline 100 nmol administered intracerebroventricularly (i.c.v.) significantly decreased spontaneous contractions of the stomach and this decrease in gastric motility was not observed in bilaterally vagotomized animals. Intracisternally administered (i.c.) noradrenaline (10 nmol) induced a decrease in gastric motility comparable to that elicited by noradrenaline 100 nmol i.c.v. Phentolamine 10 nmol i.c. but not the same dose of propranolol i.c. significantly antagonized the noradrenaline (10 nmol)-induced inhibition of gastric motility. These results suggest that alpha-adrenoceptor-mediated noradrenergic mechanisms in the brain stem are involved in the inhibitory regulation of gastric motility.

摘要

在已植入胃内气囊的乌拉坦麻醉大鼠中，研究了中枢去甲肾上腺素能机制在胃动力调节中的作用。脑室内注射（i.c.v.）100 nmol去甲肾上腺素可显著降低胃的自发收缩，而在双侧迷走神经切断的动物中未观察到这种胃动力的降低。脑池内注射（i.c.）10 nmol去甲肾上腺素引起的胃动力降低与脑室内注射100 nmol去甲肾上腺素引起的相似。脑池内注射10 nmol酚妥拉明可显著拮抗去甲肾上腺素（10 nmol）诱导的胃动力抑制，但相同剂量的普萘洛尔脑池内注射则无此作用。这些结果表明，脑干中α-肾上腺素能受体介导的去甲肾上腺素能机制参与了胃动力的抑制性调节。