Fikrig M K, Tattersall P
Department of Medicine, Yale University School of Medicine, New Haven, CT 06510.
Dev Biol Stand. 1992;76:285-93.
The parvoviruses are a family of single-stranded DNA-containing viruses which are known to establish inapparent infections of continuous, and in some cases, primary cell cultures. Their small size and great stability suggest that they would be difficult to eliminate from a biological component purified from a contaminated cell line. Thus, precautions should be taken to exclude such agents from initial cell cultures, and from the reagents used to maintain them.
细小病毒是一类含有单链DNA的病毒,已知它们能在连续的,在某些情况下是原代细胞培养物中引发隐性感染。它们体积小且稳定性高,这表明从受污染细胞系纯化得到的生物成分中很难去除它们。因此,应采取预防措施,在初始细胞培养物以及用于维持这些培养物的试剂中排除此类病原体。