Siegl G
Institute for Clinical Microbiology and Immunology, St. Gallen, Switzerland.
Behring Inst Mitt. 1990 Aug(85):6-13.
The so-called autonomous parvoviruses comprise a wide spectrum of viral agents with quite similar physicochemical and biological properties. Characteristically, they are small, naked, and extraordinarily stable particles made up of only 2-4 structural proteins and a genome of linear, single-stranded DNA consisting of 4500-5600 nts. For replication they depend on cellular helper functions which become available at distinct stages during cellular differentiation (developmentally-dependent functions) and transiently during the phase of DNA synthesis in the mitotic cycle (cell cycle-dependent function(s)) of a susceptible cell. Most of the clinical syndromes induced by parvoviruses therefore can be related to infection of mitotically active cells or tissues at different stages in the development and maturation of the host organism. This view of parvovirus pathogenicity holds true for all animal parvoviruses as well as for the human parvovirus B19.
所谓的自主性细小病毒包括多种病毒因子，它们具有颇为相似的物理化学和生物学特性。其特点是，它们是微小、无包膜且极其稳定的颗粒，仅由2 - 4种结构蛋白以及由4500 - 5600个核苷酸组成的线性单链DNA基因组构成。它们的复制依赖于细胞辅助功能，这些功能在细胞分化的不同阶段（发育依赖性功能）以及在易感细胞有丝分裂周期的DNA合成阶段短暂出现（细胞周期依赖性功能）。因此，细小病毒引起的大多数临床综合征可能与宿主生物体发育和成熟不同阶段有丝分裂活跃的细胞或组织感染有关。这种细小病毒致病性的观点适用于所有动物细小病毒以及人类细小病毒B19。
