Yamamoto Y, Saka T, Makimoto K, Takahashi H
Department of Otolaryngology, Osaka Medical College, Japan.
J Laryngol Otol. 1992 Nov;106(11):1016-20. doi: 10.1017/s0022215100121656.
Eight cases of adenoid cystic carcinoma were reviewed to determine whether and how the histological features of the tumour vary with the progress of the disease. The tumours were classified by their histological patterns as tubular, cribriform, trabecular or solid. The relative amount of each pattern seen in routine light microscopic sections was calculated histomorphometrically and compared in the primary tumour and recurrent and/or metastatic lesions in the same case. In the early stage, the tubular pattern predominated. Later, the highest percentage shifted to the cribriform, then to the trabecular and finally, in the late stage, to the solid pattern. There was no reverse direction of histological transformation from the solid to the tubular pattern. These results may help to explain previous reports that the tubular pattern usually represents a favourable prognosis, the solid pattern a poor prognosis and the cribriform pattern an intermediate prognosis.
回顾了8例腺样囊性癌病例，以确定肿瘤的组织学特征是否以及如何随疾病进展而变化。根据组织学模式将肿瘤分为管状、筛状、小梁状或实体状。通过组织形态计量学计算常规光学显微镜切片中每种模式的相对含量，并在同一病例的原发性肿瘤、复发性和/或转移性病变中进行比较。在早期，管状模式占主导。后来，最高比例转向筛状，然后是小梁状，最后在晚期转向实体状。没有从实体状到管状模式的组织学转化的反向情况。这些结果可能有助于解释先前的报道，即管状模式通常代表预后良好，实体状模式预后不良，筛状模式预后中等。
