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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Department of Biomedical Science, The University, Sheffield England.

Gen Pharmacol. 1992 Nov;23(6):945-63. doi: 10.1016/0306-3623(92)90273-m.

A range of anaesthetic agents affect the centripetal transmission of sensory transmission by activating cortico-thalamic inhibitory mechanisms. 2. This transmission of information through thalamic sensory relay nuclei is impeded and the sensory flow to the cerebral cortex is considerably reduced. 3. In addition cortical transfer of information is blocked since cells in layers III and V show an additional sensitivity to anaesthetic agents. 4. Diprivan (2,6-diisopropylphenol, propofol, ICI) appears to exert an action on sensory transmission mainly by acting on cortical cells in layers III and V. 5. Its action on thalamic sensory relay cells is to increase their latency of discharge and disrupt their pattern of firing.

一系列麻醉剂通过激活皮质 - 丘脑抑制机制影响感觉传导的向心传递。2. 通过丘脑感觉中继核的这种信息传递受到阻碍，并且流向大脑皮层的感觉信息流显著减少。3. 此外，由于III层和V层的细胞对麻醉剂表现出额外的敏感性，信息的皮质传递被阻断。4. 得普利麻（2,6 - 二异丙基苯酚，丙泊酚，ICI）似乎主要通过作用于III层和V层的皮质细胞对感觉传导发挥作用。5. 它对丘脑感觉中继细胞的作用是增加其放电潜伏期并扰乱其放电模式。

Department of Biomedical Science, The University, Sheffield England.

Gen Pharmacol. 1992 Nov;23(6):945-63. doi: 10.1016/0306-3623(92)90273-m.

A range of anaesthetic agents affect the centripetal transmission of sensory transmission by activating cortico-thalamic inhibitory mechanisms. 2. This transmission of information through thalamic sensory relay nuclei is impeded and the sensory flow to the cerebral cortex is considerably reduced. 3. In addition cortical transfer of information is blocked since cells in layers III and V show an additional sensitivity to anaesthetic agents. 4. Diprivan (2,6-diisopropylphenol, propofol, ICI) appears to exert an action on sensory transmission mainly by acting on cortical cells in layers III and V. 5. Its action on thalamic sensory relay cells is to increase their latency of discharge and disrupt their pattern of firing.

一系列麻醉剂通过激活皮质 - 丘脑抑制机制影响感觉传导的向心传递。2. 通过丘脑感觉中继核的这种信息传递受到阻碍，并且流向大脑皮层的感觉信息流显著减少。3. 此外，由于III层和V层的细胞对麻醉剂表现出额外的敏感性，信息的皮质传递被阻断。4. 得普利麻（2,6 - 二异丙基苯酚，丙泊酚，ICI）似乎主要通过作用于III层和V层的皮质细胞对感觉传导发挥作用。5. 它对丘脑感觉中继细胞的作用是增加其放电潜伏期并扰乱其放电模式。