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[隐匿性支气管类癌瘤分泌促肾上腺皮质激素,模拟库欣综合征]

[Occult bronchial carcinoid tumor producing ACTH simulating Cushing's syndrome].

作者信息

Herrera Pombo J L, Carrasco Bejar M A, Turbi Disla C, Renedo G

机构信息

Servicio de Endocrinología, Fundación Jiménez Díaz, Facultad de Medicina, Universidad Autónoma, Madrid.

出版信息

Rev Clin Esp. 1992 Dec;191(9):485-7.

PMID:1336863
Abstract

Cushing's Syndrome raises sometimes important diagnostic and therapeutic problems. A case of Cushing's Syndrome is discussed, induced by ectopic secretion of ACTH by a Benign Bronchial Carcinoid Tumor, which due to its clinical features (asymptomatic and invisible to conventional radiology and associated with typical signs of Chronic Hypercortisolism) and biochemical findings (ACTH only slightly raised and suppression with high doses dexamethasone), simulated an hypophyseal origin, the pulmonary tumor being showed only after 3 years of the diagnosis of Cushing's Syndrome.

摘要

库欣综合征有时会引发重要的诊断和治疗问题。本文讨论了一例由良性支气管类癌瘤异位分泌促肾上腺皮质激素(ACTH)引起的库欣综合征病例。由于其临床特征(无症状,常规放射学检查不可见,伴有慢性皮质醇增多症的典型体征)和生化检查结果(ACTH仅轻度升高,高剂量地塞米松可抑制),该病例模拟了垂体来源,直到库欣综合征诊断3年后肺部肿瘤才被发现。

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