Coppi G, Falcone A
Research Centre, Poli Industria Chimica, Milan, Italy.
Drugs Exp Clin Res. 1992;18(5):173-7.
Hypovolemic shock was produced in rats by withdrawing about 50% of estimated total blood volume. Following mean arterial pressure stabilization in the range of 25-27 mmHg, the rats were given intravenous ACTH (1-4) (4-9) (4-10) (5-10) (1-10) in comparison with ACTH (1-24). The ACTH fragments, administered within 5 min after shock induction, promptly and dose-dependently improved mean arterial pressure and survival of rats; the ACTH (1-10) showed an activity similar to that of ACTH (1-24) whereas the other fragments were less active.
通过抽取约50%估计的总血容量在大鼠中制造低血容量性休克。在平均动脉压稳定在25 - 27 mmHg范围内后，将大鼠静脉注射促肾上腺皮质激素（1 - 4）（4 - 9）（4 - 10）（5 - 10）（1 - 10），并与促肾上腺皮质激素（1 - 24）作比较。在休克诱导后5分钟内给予促肾上腺皮质激素片段，能迅速且剂量依赖性地改善大鼠的平均动脉压和存活率；促肾上腺皮质激素（1 - 10）显示出与促肾上腺皮质激素（1 - 24）相似的活性，而其他片段活性较低。
