Kawakami M, Kitani A, Hara M, Harigai M, Suzuki K, Kawaguchi Y, Ishii H, Kazama M, Kawagoe M, Nakamura H
First Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
J Rheumatol. 1992 Nov;19(11):1704-9.
Plasma levels of thrombomodulin and alpha 2-plasmin inhibitor-plasmin complex were measured by ELISA in patients with rheumatic diseases. Thrombomodulin levels in patients with active systemic lupus erythematosus (SLE) were significantly higher than those in patients with inactive SLE or in healthy controls. This suggests that thrombomodulin, normally a component of vascular endothelial cell membrane, is easily released to plasma in patients with active SLE. High titers of the thrombomodulin level and the correlated alpha 2-plasmin inhibitor-plasmin complex elevations imply vascular injury, and consequently, excessive fibrinolytic processes in active SLE.
采用酶联免疫吸附测定法（ELISA）检测了风湿性疾病患者血浆中血栓调节蛋白和α2 - 纤溶酶抑制物 - 纤溶酶复合物的水平。活动期系统性红斑狼疮（SLE）患者的血栓调节蛋白水平显著高于非活动期SLE患者或健康对照者。这表明，血栓调节蛋白作为血管内皮细胞膜的正常组成成分，在活动期SLE患者中容易释放到血浆中。高滴度的血栓调节蛋白水平以及相关的α2 - 纤溶酶抑制物 - 纤溶酶复合物升高意味着血管损伤，进而提示活动期SLE存在过度的纤溶过程。
