Nishimura K
Department of Respiratory Medicine, Ehime National Hospital.
Nihon Rinsho. 1992 Dec;50(12):2909-15.
The renal kallikrein-kinin system seems to participate in the regulation of blood pressure, control of sodium and water excretion, renal vascular resistance and renin release. By using ultrastructural immunocytochemistry, in situ hybridization or polymerase chain reaction experiments with the appropriate cDNA probes, kallikrein and kininogen were observed to exist and be synthesized in different types of cells of the nephron. Recently, new finding of a kinin receptor has been reported, since specific kinin receptor antagonists have become available. The localization of components of kallikrein-kinin system in the kidneys and its relation to renal function is discussed.
肾激肽释放酶 - 激肽系统似乎参与血压调节、钠和水排泄的控制、肾血管阻力以及肾素释放。通过使用超微结构免疫细胞化学、原位杂交或用适当的cDNA探针进行聚合酶链反应实验，观察到激肽释放酶和激肽原在肾单位的不同类型细胞中存在并合成。最近，由于有了特异性激肽受体拮抗剂，已有激肽受体的新发现。本文讨论了激肽释放酶 - 激肽系统各成分在肾脏中的定位及其与肾功能的关系。
