Rosti G, Albertazzi L, Tienghi A, Fiorentini G, Turci D, Cruciani G, Flamini M, Argnani M, Bassetto M A, Salvioni R
Medical Oncology Ravenna, Italy.
Leuk Lymphoma. 1992;7 Suppl:59-63. doi: 10.3109/10428199209061567.
In this paper an Italian cooperative trial investigates the role of a high-dose regimen with carboplatin, etoposide and ifosfamide in germ cell tumours. Twenty-eight patients underwent one or two transplants. Seventeen with progressive disease. Nine in sensitive relapse and two with stable disease after salvage therapy. Toxicity was generally moderate: two deaths occurred at day 15 from ABMT (one from VOD and one from tumour growth). Five patients are alive and disease free at least 10 months follow-up. In highly pre-treated patients this high-dose combination seems to give an option of cure for relapsed patients. Early transplantation is suggested.
