Del Rio G, Carani C, Bonati M, Marrama P, Della Casa L
Department of Endocrinology and Metabolism, University of Modena, Italy.
Int J Obes Relat Metab Disord. 1992 Nov;16(11):897-903.
The sex-related response of the sympathoadrenal system to very low calorie diet (VLCD) with sodium restriction has been studied in a group of 16 obese subjects (8 men; 8 women). Once in sodium balance obese men were different from women in respect to initial body weight, mean daily 4 h urinary excretion of epinephrine (E) and norepinephrine (NE) measured for 48 h. After 20 days of VLCD the weight loss was higher in men than women (P < 0.01), E excretion increased in men more than in women (P < 0.01), and was correlated with weight decrement (r = 0.78; P < 0.01). NE excretion decreased in a similar way in both sexes. The present findings demonstrate sexual dimorphism in catecholamine excretion during VLCD and provide further evidence of the relative autonomy of adrenomedullary secretion from sympathetic nervous system activity.
在一组16名肥胖受试者（8名男性，8名女性）中，研究了交感肾上腺系统对低热量饮食（VLCD）伴钠限制的性别相关反应。在钠平衡状态下，肥胖男性在初始体重、48小时内平均每日4小时尿肾上腺素（E）和去甲肾上腺素（NE）排泄量方面与女性不同。极低热量饮食20天后，男性体重减轻高于女性（P < 0.01），男性E排泄量增加幅度大于女性（P < 0.01），且与体重下降相关（r = 0.78；P < 0.01）。两性NE排泄量以相似方式下降。目前的研究结果表明，极低热量饮食期间儿茶酚胺排泄存在性别差异，并进一步证明了肾上腺髓质分泌相对于交感神经系统活动的相对自主性。
