猫免疫缺陷病毒疫苗接种后的增强反应。
Enhancement after feline immunodeficiency virus vaccination.
作者信息
Hosie M J, Osborne R, Reid G, Neil J C, Jarrett O
机构信息
University of Glasgow, Department of Veterinary Pathology, UK.
出版信息
Vet Immunol Immunopathol. 1992 Dec;35(1-2):191-7. doi: 10.1016/0165-2427(92)90131-9.
Cats were vaccinated with one of the three preparations: purified feline immunodeficiency virus (FIV) incorporated into immune stimulating complexes (ISCOMs), recombinant FIV p24 ISCOMs, or a fixed, inactivated cell vaccine in quil A. Cats inoculated with the FIV ISCOMs or the recombinant p24 ISCOMs developed high titres of antibodies against the core protein p24 but had no detectable antibodies against the env protein gp120 or virus neutralising antibodies. In contrast, all of the cats inoculated with the fixed, inactivated cell vaccine developed anti-env antibodies and four of five had detectable levels of neutralising antibody. However, none of the vaccinated cats were protected from infection after intraperitoneal challenge with 20 infectious units of FIV. Indeed there appeared to be enhancement of infection after vaccination as the vaccinated cats become viraemic sooner than the unvaccinated controls, and 100% of the vaccinated cats became viraemic compared with 78% of the controls. The mechanism responsible for this enhancement remains unknown.
用三种制剂之一对猫进行接种
掺入免疫刺激复合物（ISCOMs）的纯化猫免疫缺陷病毒（FIV）、重组FIV p24 ISCOMs或quil A中的固定化灭活细胞疫苗。接种FIV ISCOMs或重组p24 ISCOMs的猫产生了高滴度的针对核心蛋白p24的抗体，但未检测到针对包膜蛋白gp120的抗体或病毒中和抗体。相比之下，所有接种固定化灭活细胞疫苗的猫都产生了抗env抗体，五分之四的猫具有可检测水平的中和抗体。然而，在用20个感染单位的FIV进行腹腔攻击后，没有一只接种疫苗的猫受到感染保护。事实上，接种疫苗后似乎出现了感染增强的情况，因为接种疫苗的猫比未接种疫苗的对照猫更早出现病毒血症，并且100%的接种疫苗的猫出现病毒血症，而对照猫为78%。导致这种增强的机制仍然未知。
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