成人慢性活动性EB病毒感染

Chronic active Epstein-Barr virus infection in an adult.

作者信息

Sakamoto T, Uemura M, Fukui H, Yoshikawa M, Fukui K, Kinoshita K, Kojima H, Matsumori T, Tsujii T, Sumazaki R

机构信息

Third Department of Internal Medicine, Nara Medical University, Kashihara, Japan.

出版信息

Intern Med. 1992 Oct;31(10):1190-6. doi: 10.2169/internalmedicine.31.1190.

DOI:10.2169/internalmedicine.31.1190

PMID:1337484

Abstract

We report a rare adult case of chronic active Epstein-Barr virus (EBV) infection. A 54-year-old woman was admitted to our hospital with intermittent fever, weight loss, hepatosplenomegaly, pancytopenia and liver disturbance. In serological tests for EBV, anti-virus capsid antigen (VCA)-IgG antibody and anti-early antigen (EA)-IgG antibody were markedly elevated and anti-EBV nuclear antigen (EBNA) antibody was negative. EBV genome was detected in the bone marrow nucleated cells and peripheral lymphocytes by Southern blot hybridization. The patient developed left facial edema, bilateral breast tumor and pneumonia. She died one year after admission in spite of the administration of prednisolone, interferon and acyclovir.

摘要

我们报告一例罕见的成人慢性活动性爱泼斯坦-巴尔病毒（EBV）感染病例。一名54岁女性因间歇性发热、体重减轻、肝脾肿大、全血细胞减少和肝功能障碍入住我院。在EBV血清学检测中，抗病毒衣壳抗原（VCA）-IgG抗体和抗早期抗原（EA）-IgG抗体显著升高，而抗EBV核抗原（EBNA）抗体为阴性。通过Southern印迹杂交在骨髓有核细胞和外周淋巴细胞中检测到EBV基因组。患者出现左面部水肿、双侧乳腺肿瘤和肺炎。尽管给予了泼尼松龙、干扰素和阿昔洛韦治疗，她在入院一年后仍死亡。