Litwin V, Grose C
Department of Microbiology, University of Iowa College of Medicine, Iowa City.
Immunol Res. 1992;11(3-4):226-38. doi: 10.1007/BF02919129.
Nearly two decades ago, it was observed that cells infected with herpes simplex virus (HSV) acquired an IgG Fc binding activity. The properties of the viral Fc receptor (FcR) have now been characterized by several laboratories. The Fc binding activity appears on the surface of the infected cell prior to formation of progeny virions. The FcR induced by HSV has been identified as the HSV glycoprotein, gE. When HSV gE forms a complex with a second HSV glycoprotein, gI, the receptor binds IgG with higher affinity. Varicella-zoster virus (VZV), which is closely related to HSV, has also been shown to induce an FcR. Like the HSV FcR, the FcR specified by VZV possesses characteristics common to viral glycoproteins. VZV encodes two glycoproteins, gpI and gpIV, which are the homologs of HSV gE and gI. The VZV glycoproteins have many properties common to cell surface receptors, including O-linked glycans and phosphorylation sites. However, extensive computer-assisted analyses of the amino acid sequences of VZV gpI and gpIV did not uncover regions of homology to the human cellular Fc receptors for IgG.
近二十年前，人们观察到感染单纯疱疹病毒（HSV）的细胞获得了IgG Fc结合活性。现在，几个实验室已经对病毒Fc受体（FcR）的特性进行了表征。在子代病毒颗粒形成之前，Fc结合活性就出现在受感染细胞的表面。由HSV诱导的FcR已被鉴定为HSV糖蛋白gE。当HSV gE与第二种HSV糖蛋白gI形成复合物时，该受体以更高的亲和力结合IgG。与HSV密切相关的水痘带状疱疹病毒（VZV）也已被证明可诱导FcR。与HSV FcR一样，VZV指定的FcR具有病毒糖蛋白共有的特征。VZV编码两种糖蛋白，gpI和gpIV，它们是HSV gE和gI的同源物。VZV糖蛋白具有许多细胞表面受体共有的特性，包括O-连接聚糖和磷酸化位点。然而，对VZV gpI和gpIV氨基酸序列进行的广泛计算机辅助分析并未发现与人类细胞IgG Fc受体的同源区域。
