Nerem R M, Rumberger J A, Gross D R, Muir W W, Geiger G L
Cardiovasc Res. 1976 May;10(3):301-13. doi: 10.1093/cvr/10.3.301.
Coronary velocity measurements have been carried out in anaesthetized, open-chest horses using a constant-temperature, hot-film anemometer system. L-shaped needle probes inserted by direct vessel puncture have been used to measure velocity profiles in the left common, left anterior descending (LAD), and left circumflex coronary arteries. The flow conditions were characterized by peak Reynolds numbers from approximately 200 to 1500 and values of the unsteadiness parameter from 3 to 10. These measurements indicate that in the left common coronary artery the profile is in general skewed towards the outer wall as would be expected for fully viscous flow in a curved tube. In the left anterior descending and left circumflex coronary arteries just distal to the bifurcation, the skewing was found in general to be away from the flow divider. However, in regions of the LAD and left circumflex 5-6 diameters downstream of the bifurcation, the peak systolic and diastolic profiles were indicative of a more fully developed, Poiseuille type flow with only slight skewing observed. The results of this study indicate that the flow in the coronary system, though in general laminar and disturbance free, is extremely varied in character and may exhibit large amplitude, low frequency flow oscillations. Furthermore, for these vessels which all lie on the surface of the myocardium, large systolic flows were observed to be present, even though the major portion of the volume flow was reserved for the diastolic period.
已使用恒温热膜风速仪系统对麻醉开胸马的冠状动脉速度进行了测量。通过直接血管穿刺插入的L形针探头用于测量左冠状动脉主干、左前降支(LAD)和左旋支冠状动脉的速度剖面。流动条件的特征是雷诺数峰值约为200至1500,不稳定参数值为3至10。这些测量表明,在左冠状动脉主干中,剖面通常向外侧壁倾斜,这与弯曲管中完全粘性流动的预期情况一致。在分叉处远端的左前降支和左旋支冠状动脉中,发现这种倾斜通常远离分流器。然而,在分叉下游5-6个管径的左前降支和左旋支区域,收缩期和舒张期峰值剖面表明流动更充分发展,呈泊肃叶型流动,仅观察到轻微倾斜。本研究结果表明,冠状动脉系统中的流动虽然总体上是层流且无干扰,但性质极为多样,可能表现出大幅度、低频的流动振荡。此外,对于所有位于心肌表面的这些血管,即使大部分体积流量保留给舒张期,仍观察到存在较大的收缩期血流。