Olorunsogo O O, Bababunmi E A
Biochemistry Department, College of Medicine, University of Ibadan, Nigeria.
Afr J Med Med Sci. 1992 Oct;21(1):17-21.
Nifedipine, a 1,4-dihydropyridine Ca(2+)-channel blocker inhibits calmodulin-stimulated activity of erythrocyte plasma membrane (Ca(2+) + Mg2+)-ATPase. Its inhibition of the basal activity of the enzyme increases on pre-incubation with membranes. The maximum velocity, affinity for ATP and Ca(2+)-sensitivity of pump are reduced by micromolar amounts of the antihypertensive drug. These results suggest that 1,4-dihydropyridines may interact with calcium-binding proteins and calcium-dependent enzymes at their calcium-binding sites.
