钙转运ATP酶及其在肌肉和大脑中的调节。

Ca(2+)-transport ATPases and their regulation in muscle and brain.

作者信息

Wuytack F, Raeymaekers L, De Smedt H, Eggermont J A, Missiaen L, Van Den Bosch L, De Jaegere S, Verboomen H, Plessers L, Casteels R

机构信息

Katholieke Universiteit Leuven, Laboratorium voor Fysiologie, Belgium.

出版信息

Ann N Y Acad Sci. 1992 Nov 30;671:82-91. doi: 10.1111/j.1749-6632.1992.tb43786.x.

DOI:10.1111/j.1749-6632.1992.tb43786.x

PMID:1337687

Abstract

Eukaryotic cells express one or more isoforms of a sarco(endo)plasmic reticulum (SERCA) and of a plasma membrane (PMCA) Ca2+ pump. Both the SERCA and PMCA gene transcripts are subject to alternative processing in a differentiation stage-dependent and tissue-dependent manner. The Ca2+ pump isoforms thus generated may present different functional properties. This is exemplified by the SERCA2a and SERCA2b isoforms which differ in their Ca2+ sensitivity. Analysis of the cDNA structures for PMCA1 predicts protein isoforms with variant calmodulin- and phospholipid-binding domains. A comparative study of the tissue-specific mechanisms governing SERCA-PMCA transcript processing and a more detailed study of the functional implication of the PMCA pumps isoform diversity will be challenging subjects for future studies.

摘要

真核细胞表达一种或多种肌质（内质）网（SERCA）和质膜（PMCA）Ca2+泵的同工型。SERCA和PMCA基因转录本均以分化阶段依赖性和组织依赖性方式进行可变加工。由此产生的Ca2+泵同工型可能具有不同的功能特性。SERCA2a和SERCA2b同工型在Ca2+敏感性方面存在差异，这就是一个例证。对PMCA1的cDNA结构分析预测了具有可变钙调蛋白和磷脂结合结构域的蛋白质同工型。研究调控SERCA - PMCA转录本加工的组织特异性机制以及更详细地研究PMCA泵同工型多样性的功能意义，将是未来研究具有挑战性的课题。