钙信号缺陷在骨骼肌无力中的作用：药理学意义。
Role of defective Ca signaling in skeletal muscle weakness: Pharmacological implications.
作者信息
Agrawal Akanksha, Suryakumar Geetha, Rathor Richa
机构信息
DRDO, Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi, 110054, India.
出版信息
J Cell Commun Signal. 2018 Dec;12(4):645-659. doi: 10.1007/s12079-018-0477-z. Epub 2018 Jul 7.
Abstract
The misbehaving attitude of Ca signaling pathways could be the probable reason in many muscular disorders such as myopathies, systemic disorders like hypoxia, sepsis, cachexia, sarcopenia, heart failure, and dystrophy. The present review throws light upon the calcium flux regulating signaling channels like ryanodine receptor complex (RyR1), SERCA (Sarco-endoplasmic Reticulum Calcium ATPase), DHPR (Dihydropyridine Receptor) or Cav1.1 and Na+/Ca exchange pump in detail and how remodelling of these channels contribute towards disturbed calcium homeostasis. Understanding these pathways will further provide an insight for establishing new therapeutic approaches for the prevention and treatment of muscle atrophy under stress conditions, targeting calcium ion channels and associated regulatory proteins.
摘要
钙信号通路的异常行为可能是许多肌肉疾病的潜在原因，如肌病、全身性疾病如缺氧、败血症、恶病质、肌肉减少症、心力衰竭和营养不良。本综述详细阐述了调节钙通量的信号通道，如兰尼碱受体复合物（RyR1）、肌浆网钙ATP酶（SERCA）、二氢吡啶受体（DHPR）或Cav1.1以及钠/钙交换泵，以及这些通道的重塑如何导致钙稳态紊乱。了解这些通路将进一步为建立针对钙离子通道和相关调节蛋白的新治疗方法提供见解，以预防和治疗应激条件下的肌肉萎缩。
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