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金肾病：提示免疫复合物疾病的血清学数据。

Gold nephropathy: serologic data suggesting an immune complex disease.

作者信息

Palosuo T, Provost T T, Milgrom F

出版信息

Clin Exp Immunol. 1976 Aug;25(2):311-8.

PMID:133777
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1541350/
Abstract

Servlogical tests preformed on a patient with gold-induced nephropathy revealed a multitude of immunological phenomena preceding the onset of proteinuria. These included formtaion of tissue antibodies, rheumatoid factors and circulating immune complexes. An antigen sharing immunological determinants with DOC-extractable tissue antigens was released into circulation before and during proteinuria. Precipitating antibodies against this circulating antigen were found in one serum sample obtained 6 weeks before the complication was diagnosed. In this serum specimen, antibodies were also found which combined with saline extracts, DOC extracts containing the ubiquitous tissue antigen (UTA), and preparations obtained from various human organs by extraction at 100 degrees C followed by precipitation at 71% ethanol concentration (BE preparations). Most of the activities disappeared before the onset of proteinuria. The possible significance of these phenomena in the pathogenesis of nephropathy is discussed.

摘要

对一名患有金诱导性肾病患者进行的血清学检查显示，在蛋白尿发作之前出现了多种免疫现象。这些现象包括组织抗体、类风湿因子和循环免疫复合物的形成。一种与DOC可提取组织抗原有共同免疫决定簇的抗原在蛋白尿出现之前和期间释放到循环中。在并发症被诊断前6周采集的一份血清样本中发现了针对这种循环抗原的沉淀抗体。在该血清标本中，还发现了与盐水提取物、含有普遍存在的组织抗原（UTA）的DOC提取物以及通过在100℃提取然后在71%乙醇浓度下沉淀从各种人体器官获得的制剂结合的抗体。大多数活性在蛋白尿发作前消失。讨论了这些现象在肾病发病机制中的可能意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc83/1541350/c02674133ec6/clinexpimmunol00246-0133-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc83/1541350/5025ed535804/clinexpimmunol00246-0132-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc83/1541350/f645047a0780/clinexpimmunol00246-0132-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc83/1541350/5a77125be7a5/clinexpimmunol00246-0132-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc83/1541350/eb0a2c072af8/clinexpimmunol00246-0132-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc83/1541350/5a40801f000a/clinexpimmunol00246-0132-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc83/1541350/c02674133ec6/clinexpimmunol00246-0133-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc83/1541350/5025ed535804/clinexpimmunol00246-0132-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc83/1541350/f645047a0780/clinexpimmunol00246-0132-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc83/1541350/5a77125be7a5/clinexpimmunol00246-0132-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc83/1541350/eb0a2c072af8/clinexpimmunol00246-0132-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc83/1541350/5a40801f000a/clinexpimmunol00246-0132-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc83/1541350/c02674133ec6/clinexpimmunol00246-0133-a.jpg

相似文献

1
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Gold nephropathy in rabbits using an indigenous preparation. A morphological study.使用本土制剂诱导家兔金肾病：一项形态学研究
Int Urol Nephrol. 1984;16(1):49-59. doi: 10.1007/BF02082703.
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The role of hypersensitivity and the immune response in influencing susceptibility to metal toxicity.超敏反应和免疫反应在影响金属毒性易感性方面的作用。

本文引用的文献

1
Immunological studies on adrenal glands. I. Immunization with adrenals of foreign species.肾上腺的免疫学研究。I. 用异种动物肾上腺进行免疫接种。
Immunology. 1962 Jan;5(1):46-66.
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DEMONSTRATION OF SKIN ANTIBODIES IN SERA OF PEMPHIGUS VULGARIS PATIENTS BY INDIRECT IMMUNOFLUORESCENT STAINING.通过间接免疫荧光染色法在寻常型天疱疮患者血清中检测皮肤抗体
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The latex fixation test. I. Application to the serologic diagnosis of rheumatoid arthritis.乳胶凝集试验。I. 在类风湿性关节炎血清学诊断中的应用。
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Use of anti-Rh sera for demonstrating agglutination activating factor in rheumatoid arthritis.使用抗Rh血清来证明类风湿性关节炎中的凝集激活因子。
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Characteristics of a soluble nuclear antigen precipitating with sera of patients with systemic lupus erythematosus.一种可与系统性红斑狼疮患者血清沉淀的可溶性核抗原的特征
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Interaction in human blood platelets, viruses and antibodies. I. Platelet aggregation test with microequipment.人体血小板、病毒与抗体之间的相互作用。I. 微型设备血小板聚集试验
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Detection and characterization of immune complexes by the platelet aggregation test. I. Complexes formed in vitro.通过血小板聚集试验检测和鉴定免疫复合物。I. 体外形成的复合物。
Clin Exp Immunol. 1971 Mar;8(3):389-97.
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Gold nephropathy. A clinical and pathologic study.金肾病。一项临床与病理研究。
Arthritis Rheum. 1970 Nov-Dec;13(6):812-25. doi: 10.1002/art.1780130611.
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Immunochemical quantitation of antigens by single radial immunodiffusion.通过单向辐射免疫扩散法对抗原进行免疫化学定量。
Immunochemistry. 1965 Sep;2(3):235-54. doi: 10.1016/0019-2791(65)90004-2.
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Autologous immune complex nephritis induced with renal tubular antigen. I. Identification and isolation of the pathogenetic antigen.肾小管抗原诱导的自体免疫复合物肾炎。I. 致病抗原的鉴定与分离
J Exp Med. 1968 Mar 1;127(3):555-72. doi: 10.1084/jem.127.3.555.