氢氯噻嗪诱发的肺水肿：一例病例报告及文献综述

Hydrochlorothiazide-induced pulmonary edema: a case report and literature review.

作者信息

Shieh C M, Chen C H, Tao C W, Tsai J J, Perng R P

机构信息

Department of Chest Medicine, Veterans General Hospital-Taipei, Taiwan, R.O.C.

出版信息

Zhonghua Yi Xue Za Zhi (Taipei). 1992 Dec;50(6):495-9.

PMID:1338027

Abstract

A 67-year-old man developed non-cardiogenic pulmonary edema after taking a hydrochlorothiazide (HCTZ) tablet. The symptoms remitted following supportive treatment but recurred after rechallenge. Immunologic studies showed increased immunoglobulin E, negative lymphocyte transformation test when exposed to HCTZ, normal blood lymphocyte subpopulations and complement levels, and negative antinuclear antibodies. We reviewed 22 previous reported cases and emphasized that physicians should be aware of this rare but life-threatening reaction.

摘要

一名67岁男性在服用一片氢氯噻嗪（HCTZ）后出现非心源性肺水肿。经支持治疗后症状缓解，但再次用药后复发。免疫学研究显示免疫球蛋白E升高，接触HCTZ时淋巴细胞转化试验阴性，血液淋巴细胞亚群和补体水平正常，抗核抗体阴性。我们回顾了之前报道的22例病例，并强调医生应意识到这种罕见但危及生命的反应。