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[更昔洛韦联合静脉注射巨细胞病毒超免疫球蛋白治疗巨细胞病毒肺炎:病例报告]

[Cytomegalovirus pneumonia treated with ganciclovir and intravenous CMV-hyperimmune globulin: case report].

作者信息

Kitagawa K, Tashiro T, Shigeno H, Nakayama T, Kikuchi H, Nasu M

机构信息

Second Department of Internal Medicine, Oita Medical University, Japan.

出版信息

Kansenshogaku Zasshi. 1992 Oct;66(10):1488-91. doi: 10.11150/kansenshogakuzasshi1970.66.1488.

Abstract

A 60-year-old male with adult T-cell leukemia (ATL) complained of fever, cough and dyspnea, after anti-leukemic chemotherapy. Chest X-ray film showed a diffuse interstitial shadow, and cytomegalic inclusions and cytomegalovirus (CMV) antigen were detected in the bronchoalveolar lavage specimen and sputum. The diagnosis of CMV pneumonia was made, then ganciclovir and intravenous CMV-hyperimmune globin was administered. Although CMV pneumonia was improved with the treatment, the patient died of ATL. There was no cytomegalic inclusions in the lung but in the adrenal at autopsy. The combination therapy of ganciclovir and intravenous CMV-hyperimmune globulin is considered to be effective for CMV pneumonia.

摘要

一名60岁患有成人T细胞白血病(ATL)的男性在接受抗白血病化疗后出现发热、咳嗽和呼吸困难。胸部X线片显示弥漫性间质阴影,支气管肺泡灌洗标本和痰液中检测到巨细胞包涵体和巨细胞病毒(CMV)抗原。诊断为CMV肺炎,随后给予更昔洛韦和静脉注射CMV高免疫球蛋白。尽管经治疗CMV肺炎有所改善,但患者死于ATL。尸检时肺部未发现巨细胞包涵体,而肾上腺有。更昔洛韦和静脉注射CMV高免疫球蛋白联合治疗被认为对CMV肺炎有效。

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