Pasotti D, Mazzone A, Rossi M, Ricevuti G
Senior Institute of Health, Rome, Italy.
Funct Neurol. 1992 Nov-Dec;7(6):445-9.
The effect of the opioid agonist morphine and of the (-) and (+) stereoisomers of the antagonist naloxone were studied on the O2-generation from human granulocytes. Morphine or naloxone had no effect on basal or phorbol myristate acetate (PMA) stimulated O2-generation, while equimolar (-) naloxone and morphine concentrations (1 x 10-13 - 1 x 10-7 M) inhibited the stimulated O2-generation. The effect of (-) naloxone was stereospecific, suggesting the involvement of opioid receptors. The unmasking of non opioid effects of morphine could be responsible for the inhibition of O2-generation. It is suggested that the opioid control of oxidative metabolism in human granulocytes could involve multiple receptors mediating opposite effect.
研究了阿片类激动剂吗啡以及拮抗剂纳洛酮的（-）和（+）立体异构体对人粒细胞产生活氧（O₂）的影响。吗啡或纳洛酮对基础状态或佛波酯（PMA）刺激的O₂生成没有影响，而等摩尔浓度的（-）纳洛酮和吗啡（1×10⁻¹³ - 1×10⁻⁷ M）可抑制刺激后的O₂生成。（-）纳洛酮的作用具有立体特异性，提示阿片受体参与其中。吗啡非阿片类效应的暴露可能是抑制O₂生成的原因。有人提出，阿片类对人粒细胞氧化代谢的调控可能涉及介导相反作用的多种受体。
