Iwase S, Mano T, Saito M, Ishida G
Department of Autonomic and Behavioral Neurosciences, Nagoya University, Japan.
Funct Neurol. 1992 Nov-Dec;7(6):459-70.
The sympatho-modulating effects of eperisone hydrochloride, a centrally acting muscle relaxant, on microneurographically recorded muscle sympathetic nerve activity (MSA) were analyzed in human volunteers. A single dose of 300 mg of eperisone was orally administered to 19 healthy subjects aged between 19 and 27, and effects on 1) spontaneous MSA in 30 degrees head-up tilted position, 2) resting MSA and responsiveness to standing, 3) exercise-induced enhancement of MSA were observed. Eperisone has a sympatho-suppressive action in resting skeletal muscles, but has no effect on MSA in actively contracting muscles, e.g. standing, hand-gripping. The sympatho-suppressive effect of eperisone may be related to the drug-induced increase of blood low in the resting skeletal muscles; also it may be one more mechanism through which the drug can exert its muscle relaxant action.
在人类志愿者中分析了中枢性肌肉松弛剂盐酸乙哌立松对微神经图记录的肌肉交感神经活动（MSA）的交感神经调节作用。对19名年龄在19至27岁之间的健康受试者口服单剂量300 mg乙哌立松，并观察其对1）30度头高位倾斜姿势下的自发性MSA、2）静息MSA及对站立的反应性、3）运动诱导的MSA增强的影响。乙哌立松在静息骨骼肌中具有交感抑制作用，但对主动收缩肌肉（如站立、握力）的MSA无影响。乙哌立松的交感抑制作用可能与药物诱导的静息骨骼肌中血液减少有关；这也可能是该药物发挥肌肉松弛作用的另一种机制。
