Bruce A G, Linsley P S, Rose T M
Bristol-Myers Squibb, Pharmaceutical Research Institute-Seattle, WA 98121.
Prog Growth Factor Res. 1992;4(2):157-70. doi: 10.1016/0955-2235(92)90029-h.
Oncostatin M (OSM) was initially identified as a polypeptide cytokine which inhibited the in vitro growth of cells from melanoma and other solid tumors. OSM shows significant similarities in primary amino acid sequence and predicted secondary structure to leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), granulocyte colony-stimulating factor (G-CSF), interleukin 6 (IL-6), and interleukin 11 (IL-11). Analysis of the genes encoding these proteins reveals a shared exon organization suggesting evolutionary descent from a common ancestral gene. Recent data indicates that OSM also shares a number of in vitro activities with other members of this cytokine family. The overlapping biological effects appear to be explained by the sharing of receptor subunits.
抑瘤素M（OSM）最初被鉴定为一种多肽细胞因子，它能抑制黑色素瘤和其他实体瘤细胞的体外生长。OSM在一级氨基酸序列和预测的二级结构上与白血病抑制因子（LIF）、睫状神经营养因子（CNTF）、粒细胞集落刺激因子（G-CSF）、白细胞介素6（IL-6）和白细胞介素11（IL-11）具有显著相似性。对编码这些蛋白质的基因分析表明，它们具有共同的外显子组织，提示它们是由一个共同的祖先基因进化而来。最近的数据表明，OSM在体外也与该细胞因子家族的其他成员具有一些共同活性。重叠的生物学效应似乎可以通过受体亚基的共享来解释。
