Belangero V M, Collares E F
Departamento de Pediatria da FCM-UNICAMP.
Arq Gastroenterol. 1992 Jan-Mar;29(1):23-7.
The gastric emptying of a 0.25 M sodium bicarbonate solution was studied in rats with metabolic acidosis induced by a previous (6 hours) orogastric infusion of a 0.5 M ammonium chloride solution. Two control groups were used: one previously infused with 0.5 M sodium chloride and the other with water, in the same volume that further solutions. Every animal was fed with 2 ml/100 g of its weight of these solutions. The test meal (bicarbonate solution) was utilized containing 6 mg% red fenol as a marker. The gastric retentions were determined 6 hours after those first meals at 5, 10, 20 and 30 minutes. The results demonstrated that the gastric retentions of the bicarbonate solution were significantly lower in the acidotic group than that one of water group (at 20 minutes) and that one of the sodium chloride (at 10, 20 and 30 minutes). The data here presented suggest that metabolic acidosis accelerates the gastric emptying of a sodium bicarbonate solution.
在先前（6小时）经口胃内输注0.5M氯化铵溶液诱导代谢性酸中毒的大鼠中，研究了0.25M碳酸氢钠溶液的胃排空情况。使用了两个对照组：一组先前输注0.5M氯化钠，另一组输注水，输注体积与后续溶液相同。每只动物按每100克体重喂食2毫升这些溶液。测试餐（碳酸氢钠溶液）中含有6mg%的红色酚作为标记物。在首次喂食后6小时的5、10、20和30分钟测定胃潴留量。结果表明，酸中毒组碳酸氢钠溶液的胃潴留量显著低于水组（20分钟时）和氯化钠组（10、20和30分钟时）。此处呈现的数据表明，代谢性酸中毒会加速碳酸氢钠溶液的胃排空。
