Muylle L, Wouters E, De Bock R, Peetermans M E
Blood Transfusion Center Antwerpen, Belgian Red Cross, Edegem.
Transfus Med. 1992 Dec;2(4):289-93. doi: 10.1111/j.1365-3148.1992.tb00172.x.
Random platelet concentrates were pooled and depleted of leucocytes by centrifugation immediately prior to transfusion. The incidence and severity of reactions to 570 leucocyte-poor platelet transfusions in 74 patients were studied. An overall transfusion reaction rate of 13.7% was observed. The reaction rate to platelets stored for less than 3 days (8.7%) was significantly different from the reaction rate to platelets stored for 3 days or more (17.6%). Minor reactions as well as moderate and severe reactions were more frequent in the latter group. As most of the white blood cells were removed prior to transfusion, it is suggested that the reactions result from the transfusion of pyrogenic and/or vasoactive substances accumulated in the plasma of the concentrate during storage.
随机采集的血小板浓缩液在输血前立即通过离心进行白细胞去除处理。对74例患者的570次少白细胞血小板输血反应的发生率和严重程度进行了研究。观察到总体输血反应率为13.7%。储存时间少于3天的血小板的反应率（8.7%）与储存3天或更长时间的血小板的反应率（17.6%）有显著差异。后一组中轻微反应以及中度和重度反应更为频繁。由于大多数白细胞在输血前已被去除，因此提示这些反应是由储存期间浓缩液血浆中积累的致热物质和/或血管活性物质的输血所致。
