Simon P, Babin S R, Delloye C, Schmitt D
Départment d'orthopédie et de traumatologie, hôpital de Hautepierre, Strasbourg.
Chirurgie. 1992;118(3):144-8.
Incorporation of massive cortical bone allografts in human is slow and remains incomplete. Late biopsies of implanted allografts or histological studies of explanted allografts always show the partial substitution of necrotic bone by new bone from the host. The aim of the present study was to evaluate the effect of drilling the massive deep-frozen cortical allografts in order to induce osteogenesis. Thirteen sheep were operated on and a standard segment of the proximal ulna was removed and the gap filled either by an unperforated allograft or by a perforated one. Based on histological and microradiographic examination, a quite complete substitution of the perforated allografts was observed but in this model no statistically significant difference was observed between perforated and unperforated allografts. Further study is needed to assess the effect of the perforations.
在人体中植入大块皮质骨异体骨的过程缓慢且不完全。对植入异体骨的后期活检或对取出异体骨的组织学研究总是显示，坏死骨被宿主的新骨部分替代。本研究的目的是评估对大块深度冷冻皮质异体骨进行钻孔以诱导成骨的效果。对13只绵羊进行手术，切除尺骨近端的标准节段，并用未穿孔的异体骨或穿孔的异体骨填充间隙。基于组织学和显微放射学检查，观察到穿孔异体骨有相当完全的替代，但在该模型中，穿孔异体骨和未穿孔异体骨之间未观察到统计学上的显著差异。需要进一步研究来评估穿孔的效果。
