Karam K, Sayegh R, Saadeh G, Saba M
Department of Obstetrics and Gynecology, American University, Beirut Medical Center.
J Med Liban. 1992;40(1):31-5.
FSH and LH secreting pituitary adenomas may not be as rare as has been previously thought. Women in their reproductive years with a normal estrogenic state and hypergonadotropic amenorrhea should be suspected to harbor a pituitary microadenoma secreting gonadotropins. A computerized tomogram of the pituitary confirms the diagnosis. Two such cases who underwent transphenoidal resection of their adenomas are presented. Pituitary dynamic testing is normal in both. Laparoscopic directed ovarian biopsies show primordial follicles in one and a corpus luteum in the other. Transphenoidal resection, with the risk of permanent hypopituitarism, should be weighed against expectant management, with periodic evaluation of pituitary functions, until the natural history of these adenomas is uncovered.
分泌促卵泡生成素（FSH）和促黄体生成素（LH）的垂体腺瘤可能并不像之前认为的那样罕见。处于生殖年龄、雌激素状态正常且伴有高促性腺激素性闭经的女性，应怀疑患有分泌促性腺激素的垂体微腺瘤。垂体计算机断层扫描可确诊。本文介绍了两例接受经蝶窦腺瘤切除术的此类病例。两人的垂体动态测试均正常。腹腔镜引导下的卵巢活检显示，其中一人有原始卵泡，另一人有黄体。经蝶窦切除术有导致永久性垂体功能减退的风险，应与期待性管理进行权衡，即定期评估垂体功能，直至揭示这些腺瘤的自然病程。
