Bonhomme A, Pingret L, Pinon J M
Unité INSERM U. 314, Reims, France.
Parassitologia. 1992 Dec;34(1-3):31-43.
Toxoplasma gondii, the etiologic agent of toxoplasmosis, is a ubiquitous protozoan parasite that requires an intracellular site for growth and replication. The invasive process involves six steps: a) cellular recognition, b) parasite movements by means of a subpellicular microtubule cytoskeleton, c) cell to cell adhesion, d) rhoptry secretion of penetrating enhancing factor (PEF) with Ca++ and Ca++ activated ATPase dependence, e) conoid penetration, f) induction of a parasitophorous vacuole, a protective and exchange site, interiorization of the parasite. The invasion is an active, oriented and specific process depending on chemical factors as energy sources, cations, as well as microviscosity and membrane structures. Toxoplasma gondii stimulates T cell subsets and induces lymphokine (IFN gamma, IL2) release.
弓形虫是弓形虫病的病原体，是一种普遍存在的原生动物寄生虫，需要在细胞内生长和繁殖。侵入过程包括六个步骤：a）细胞识别；b）借助表膜下微管细胞骨架进行寄生虫运动；c）细胞间粘附；d）在钙离子及钙离子激活的ATP酶依赖作用下，棒状体分泌穿透增强因子（PEF）；e）锥状体穿透；f）诱导形成一个寄生泡，这是一个保护性和交换位点，使寄生虫内化。侵入是一个主动、定向且特异的过程，依赖于化学因子作为能量来源、阳离子以及微粘度和膜结构。弓形虫刺激T细胞亚群并诱导淋巴因子（γ干扰素、白细胞介素2）释放。
