Rorsman F, Betsholtz C
Department of Pathology, University Hospital, Uppsala, Sweden.
Growth Factors. 1992;6(4):303-13. doi: 10.3109/08977199209021542.
The mouse platelet-derived growth factor (PDGF) A-chain gene has been structurally characterized and compared with its human counterpart. The organization of the two genes is similar. Both consist of 7 exons spaced by 6 introns of corresponding sizes. As in the human gene, exon 6 encodes a sequence which is alternatively spliced. When present, it codes for an alternative C-terminus of the A-chain. In intron 5, conserved stretches of nucleotides, potentially involved in the regulation of the alternative splicing, are identified. The untranslated sequences show a high degree of nucleotide sequence identity and several conserved consensus binding sites for transcription factors are identified within the 5' untranslated as well as in the 5' flanking region.
小鼠血小板衍生生长因子（PDGF）A链基因已在结构上进行了表征，并与其人类对应基因进行了比较。这两个基因的组织方式相似。它们都由7个外显子组成，中间间隔着6个大小相应的内含子。与人基因一样，外显子6编码一个可选择性剪接的序列。当该序列存在时，它编码A链的一个可变C末端。在内含子5中，鉴定出了可能参与选择性剪接调控的保守核苷酸序列。非翻译序列显示出高度的核苷酸序列同一性，并且在5'非翻译区以及5'侧翼区域内鉴定出了几个保守的转录因子共有结合位点。
